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Allele Symbol Allele Name Allele ID |
Tg(CAG-Tle1,-ALPP)1Lbe transgene insertion 1, Corrinne Lobe MGI:3697397 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only 50% (6/12) double transgenic mice have visible tumors on the pleural surface compared to 96% (27/28) of Tg(ACTB-Tle1,-ALPP)1Lbe single transgenics at 6 months of age
• average number of visible tumors is 2.4 compared to 8.3 in single transgenic mice; tumors are substantially smaller in addition to being decreased in number
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• adults develop lung tumors with 100% penetrance
• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern
• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse
• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis
• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae
• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei
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• adults develop lung tumors with 100% penetrance
• neoplasms appear at 1 month resembling noninvasive bronchioalveolar carcinoma; at 3-5 months, visible tumor nodules are noted on the pleural surface with extensive proliferation, but preserving their bronchioalveolar growth pattern
• between 5 and 6 months, number of visible lesions on pleural surface increases from 3.2 to 8.3/mouse
• by 8 months, some lesions appear as whitish solid tumor masses characteristic of invasive cancer; such tumors replace large areas of lung parenchyma and show areas of necrosis
• tumor cells are tall columnar epithelial cells showing a mix of papillary, acinar, as well as bronchioalveolar growth patterns; there is prominent extracellular mucin secretion that causes destruction of alveolar septae
• alveolar and terminal bronchioles are lined with dysplastic epithelial cells with pleomorphic, enlarged ,irregular nuclei
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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