Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad1l1tm1.1Ktj mutation
(0 available);
any
Mad1l1 mutation
(65 available)
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mortality/aging
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• no homozygous pups are born
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Allelic
Composition |
Mad1l1tm1.1Ktj/Mad1l1+
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Genetic
Background |
involves: BALB/c * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad1l1tm1.1Ktj mutation
(0 available);
any
Mad1l1 mutation
(65 available)
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cellular
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• chromosomal instability is much higher than in wild-type MEFs
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• 6% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
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• mutant MEFs injected into athymic nude mice produced tumors in 3/8 mice compared to no tumors from wild-type MEFs; tumors grow slowly and are not palpable until weeks 6 to 10
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• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
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neoplasm
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• when assayed at 18 moths of age, heterozygotes show increased tumor incidence compared to wild-type
• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
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• uterine carcinoma is observed in some mice at 18 months of age
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• uterine sarcoma is observed in some mice at 18 months of age
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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skeleton
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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respiratory system
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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muscle
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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liver/biliary system
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• observed in some mice at 18 months of age with higher incidence than in wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mad1l1tm1.1Ktj mutation
(0 available);
any
Mad1l1 mutation
(65 available)
Mad2l1tm1Sorg mutation
(1 available);
any
Mad2l1 mutation
(14 available)
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neoplasm
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• mutant MEFs induce tumors in 100% of athymic nude mice in 4 weeks
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cellular
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• chromosomal instability is much higher than in wild-type MEFs
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• 14.5% of MEFs are aneuploid for chromosome 2 compared to 1.4% of wild-type MEFs
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• mutant MEFs injected into athymic nude mice produced tumors in 8/8 mice within 4 weeks compared to no tumors from wild-type MEFs
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• stringency of spindle assembly checkpoint (SAC) mediated arrest in response to nocodazole is weaker in mutant MEFs
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Analysis Tools