Phenotypes associated with this allele

• Allele Symbol: Plce1^tm1Avsm
• Allele Name: targeted mutation 1, Alan V Smrcka
• Allele ID: MGI:3697316
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plce1^tm1Avsm/Plce1^tm1Avsm	B6.129S6-Plce1^tm1Avsm	MGI:5304299
hm2	Plce1^tm1Avsm/Plce1^tm1Avsm	involves: 129S6/SvEvTac * C57BL/6	MGI:3697443

Genotype
MGI:5304299

hm1

• Allelic Composition: Plce1^tm1Avsm/Plce1^tm1Avsm
• Genetic Background: B6.129S6-Plce1^tm1Avsm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal calcium ion homeostasis ( J:179540 )

• Calcium-induced Ca²⁺ release induced by cAMP elevating agents is either reduced or lost in pancreatic beta cells

Genotype
MGI:3697443

hm2

• Allelic Composition: Plce1^tm1Avsm/Plce1^tm1Avsm
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

cardiovascular system

decreased cardiac muscle contractility ( J:117556 )

• conscious, unanesthetized mutants at 2, 4, and 6 months of age, have increased systolic left ventricle dimension, decreased fractional shortening, and a slower mean velocity of circumferential fiber shortening

• baseline LV dP/dt is normal, however, the increase in LV dP/dt in response to acute doses of isoproterenol is blunted by nearly 50%

abnormal myocardial fiber physiology ( J:117556 )

• isolated cardiac myocytes show a 40% decrease in beta-adrenergic receptor-dependent increases in calcium transient amplitudes

increased response of heart to induced stress ( J:117556 )

• exhibit enhanced susceptibility to cardiac hypertrophy and fibrosis in response to chronic isoproterenol-induced stress

muscle

decreased cardiac muscle contractility ( J:117556 )

• conscious, unanesthetized mutants at 2, 4, and 6 months of age, have increased systolic left ventricle dimension, decreased fractional shortening, and a slower mean velocity of circumferential fiber shortening

• baseline LV dP/dt is normal, however, the increase in LV dP/dt in response to acute doses of isoproterenol is blunted by nearly 50%

homeostasis/metabolism

increased response of heart to induced stress ( J:117556 )

• exhibit enhanced susceptibility to cardiac hypertrophy and fibrosis in response to chronic isoproterenol-induced stress