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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mcm4Gt(RRE056)Byg
gene trap RRE056, BayGenomics
MGI:3696796
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mcm4Gt(RRE056)Byg/Mcm4Gt(RRE056)Byg involves: 129P2/OlaHsd MGI:3696825
ht2
 		Mcm4Gt(RRE056)Byg/Mcm4+ involves: 129P2/OlaHsd MGI:3696831
ht3
 		Mcm4Gt(RRE056)Byg/Mcm4+ involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838128
ht4
 		Mcm4chaos3/Mcm4Gt(RRE056)Byg B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg MGI:3696836
ht5
 		Mcm4chaos3/Mcm4Gt(RRE056)Byg involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:3696840
cx6
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838127
cx7
 		Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838129
cx8
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838137
cx9
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm4Gt(RRE056)Byg/Mcm4+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838121
cx10
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838122
cx11
 		Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838125
cx12
 		Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+ 		involves: 129P2/OlaHsd * C3HeB/FeJ MGI:4838126
cx13
 		Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4chaos3/Mcm4Gt(RRE056)Byg 		involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J MGI:4838113


Genotype
MGI:3696825
hm1
Allelic
Composition		 Mcm4Gt(RRE056)Byg/Mcm4Gt(RRE056)Byg
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
absent inner cell mass proliferation ( J:117494 )
• proliferation of inner cell mass is not observed in blastocyst cultures

cellular
absent inner cell mass proliferation ( J:117494 )
• proliferation of inner cell mass is not observed in blastocyst cultures




Genotype
MGI:3696831
ht2
Allelic
Composition		 Mcm4Gt(RRE056)Byg/Mcm4+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:117494 )
• mice appear normal




Genotype
MGI:4838128
ht3
Allelic
Composition		 Mcm4Gt(RRE056)Byg/Mcm4+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:3696836
ht4
Allelic
Composition		 Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic
Background		 B6.Cg-Mcm4chaos3 Mcm4Gt(RRE056)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:117494 )
• embryos are found until E14.5
• Background Sensitivity: on mixed backgrounds, mutants show extended survival

embryo
embryonic growth retardation ( J:117494 )
• majority are growth retarded

growth/size/body
embryonic growth retardation ( J:117494 )
• majority are growth retarded

cellular
abnormal cell cycle ( J:117494 )
• there are a lower number of cells in S phase and slightly increased G2/M populations compared to controls
decreased fibroblast proliferation ( J:117494 )
• mouse embryonic fibroblasts (MEFs) show a mild defect in proliferation
induced chromosome breakage ( J:117494 )
• MEFs are highly susceptible to aphidicolin-induced chromosome breaks




Genotype
MGI:3696840
ht5
Allelic
Composition		 Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, incomplete penetrance ( J:117494 , J:165667 )
• double mutants are observed at E18.5; a small number survive past birth (J:117494)
• Background Sensitivity: survival is extended compared to B6 congenic background (J:117494)
• fewer than expected mice are alive at birth (J:165667)
postnatal lethality, incomplete penetrance ( J:165667 )
• very few mice are present at weaning

growth/size/body
fetal growth retardation ( J:117494 )
• at E18.5, animals are markedly smaller than control littermates

digestive/alimentary system
abnormal digestive system development ( J:117494 )
• mice surviving to P2 show abnormal development of digestive system; milk spot appears diffuse and spread out over entire abdomen




Genotype
MGI:4838127
cx6
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838129
cx7
Allelic
Composition		 Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838137
cx8
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Mcm7Gt(YTA285)Byg/Mcm7+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
Mcm7Gt(YTA285)Byg mutation (0 available); any Mcm7 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838121
cx9
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm4Gt(RRE056)Byg/Mcm4+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838122
cx10
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838125
cx11
Allelic
Composition		 Mcm2Gt(AB0178)Wtsi/Mcm2+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm2Gt(AB0178)Wtsi mutation (0 available); any Mcm2 mutation (49 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838126
cx12
Allelic
Composition		 Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4Gt(RRE056)Byg/Mcm4+
Mcm6Gt(YHD248)Byg/Mcm6+
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
Mcm6Gt(YHD248)Byg mutation (0 available); any Mcm6 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
chromosomal instability ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice

hematopoietic system
abnormal erythrocyte morphology ( J:165667 )
• mice exhibit an increase in micronuclei containing red blood cells indicating increased genome instability compared with wild-type mice




Genotype
MGI:4838113
cx13
Allelic
Composition		 Mcm3Gt(RRR002)Byg/Mcm3+
Mcm4chaos3/Mcm4Gt(RRE056)Byg
Genetic
Background		 involves: 129P2/OlaHsd * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mcm3Gt(RRR002)Byg mutation (0 available); any Mcm3 mutation (43 available)
Mcm4chaos3 mutation (1 available); any Mcm4 mutation (42 available)
Mcm4Gt(RRE056)Byg mutation (0 available); any Mcm4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:165667 )
• mice die sooner than Mcm4chaos3 homozygotes
postnatal lethality, incomplete penetrance ( J:165667 )
• postnatal mortality observed in Mcm4chaos3/Mcm4Gt(RRE056)Byg mice is partially rescued

neoplasm

endocrine/exocrine glands

integument




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory