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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SOD1)76Dpr
transgene insertion 76, Donald L Price
MGI:3695886
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Nos1tm1Plh/Nos1tm1Plh
Tg(SOD1)76Dpr/0 		involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J MGI:4366928
cx2
 		Tg(APPV717I)1130Kha/0
Tg(SOD1)76Dpr/0 		involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3722319
cx3
 		Tg(APP)6209Kha/0
Tg(SOD1)76Dpr/0 		involves: C3H/HeJ * C57BL/6J * FVB/N MGI:3722320
tg4
 		Tg(SOD1)76Dpr/0 B6.Cg-Tg(SOD1)76Dpr MGI:4366927
tg5
 		Tg(SOD1)76Dpr/0 involves: C3H/HeJ * C57BL/6J MGI:3814061


Genotype
MGI:4366928
cx1
Allelic
Composition		 Nos1tm1Plh/Nos1tm1Plh
Tg(SOD1)76Dpr/0
Genetic
Background		 involves: 129S4/SvJae * C3H/HeJ * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation (3 available); any Nos1 mutation (82 available)
Tg(SOD1)76Dpr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to ischemic brain injury ( J:128835 )
• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls but not compared to mice hemizygous for Tg(SOD1)76Dpr alone
decreased cerebral infarct size ( J:128835 )
• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls
• however, the reduction in infarction size is not significantly different from that seen in mice hemizygous for Tg(SOD1)76Dpr alone

homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:128835 )
• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls but not compared to mice hemizygous for Tg(SOD1)76Dpr alone
decreased cerebral infarct size ( J:128835 )
• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls
• however, the reduction in infarction size is not significantly different from that seen in mice hemizygous for Tg(SOD1)76Dpr alone




Genotype
MGI:3722319
cx2
Allelic
Composition		 Tg(APPV717I)1130Kha/0
Tg(SOD1)76Dpr/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:43446 )
• 1/7 animals died prior to 170 days




Genotype
MGI:3722320
cx3
Allelic
Composition		 Tg(APP)6209Kha/0
Tg(SOD1)76Dpr/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:43446 )
N
• no animals die prior to 170 days




Genotype
MGI:4366927
tg4
Allelic
Composition		 Tg(SOD1)76Dpr/0
Genetic
Background		 B6.Cg-Tg(SOD1)76Dpr
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased susceptibility to ischemic brain injury ( J:128835 )
• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls
decreased cerebral infarct size ( J:128835 )
• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls
• infarct size is also reduced compared to Nos1 null mice

homeostasis/metabolism
decreased susceptibility to ischemic brain injury ( J:128835 )
• functional deficits following middle cerebral artery obstruction are reduced compared to wild-type controls
decreased cerebral infarct size ( J:128835 )
• infarction sized induced by middle cerebral artery obstruction is reduced compared to wild-type controls
• infarct size is also reduced compared to Nos1 null mice




Genotype
MGI:3814061
tg5
Allelic
Composition		 Tg(SOD1)76Dpr/0
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:69178 )
• mice exhibit no clinical phenotypes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory