Phenotypes associated with this allele

• Allele Symbol: Otx2^tm1.1Tlam
• Allele Name: targeted mutation 1.1, Thomas Lamonerie
• Allele ID: MGI:3695699
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Otx2^tm1.1Tlam/Otx2^tm2(cre/ERT2)Tlam	129/Sv	MGI:3696788

Genotype
MGI:3696788

cn1

• Allelic Composition: Otx2^tm1.1Tlam/Otx2^{tm2(cre/ERT2)Tlam}
• Genetic Background: 129/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:116888 )

• when embryos receive tamoxifen on 10.5, only 5% survive to P10, although numbers are normal at E18.5

• when embryos receive tamoxifen on 12.5 or later, viability is not compromised

growth/size/body

decreased body size ( J:116888 )

• when embryos receive tamoxifen on E12.5 but not at E14.5 or 16.5, animals are consistently smaller than normal littermates at 10 weeks of age

postnatal growth retardation ( J:116888 )

craniofacial

abnormal mandible morphology ( J:116888 )

• when embryos receive tamoxifen on E14.5, inferior colliculi show improved development but do not join medially

nervous system

abnormal forebrain development ( J:116888 )

• when embryos receive tamoxifen on E7.5, absence or reduction of forebrain is seen at E9.5

abnormal midbrain morphology ( J:116888 )

• when embryos receive tamoxifen on E12.5, a posterior medial part of dorsal midbrain adopt a cerebellar histology and form granule layers; in adults, structure shows cerebellar organization with Purkinje cells, interneurons and internal granule cells

abnormal inferior colliculus morphology ( J:116888 )

• when embryos receive tamoxifen on E14.5, inferior colliculi show improved development but do not join medially

decreased inferior colliculus size ( J:116888 )

• when embryos receive tamoxifen on E12.5, a large medial portion of inferior colliculus is missing

loss of dopaminergic neurons ( J:116888 )

• population in embryos receiving tamoxifen injection on E10.5 and 12.5 is reduced in ventral midbrain

skeleton

abnormal mandible morphology ( J:116888 )

• when embryos receive tamoxifen on E14.5, inferior colliculi show improved development but do not join medially

vision/eye

abnormal eye development ( J:116888 )

• when embryos receive tamoxifen on E7.5, absence or reduction of eye is seen at E9.5