All Phenotypes Krt4<Bcc1> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Krt4^Bcc1/Krt4^Bcc1	C3HeB/FeJ-Krt4^Bcc1	MGI:3695719
ht2	Krt4^Bcc1/Krt4⁺	C3HeB/FeJ-Krt4^Bcc1	MGI:3695720

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:116740 )

• slight but significant reduction in survival

craniofacial

abnormal oral mucosa morphology ( J:116740 )

• mild lymphocytic infiltration in the submucosa

oral leukoplakia ( J:116740 )

• primarily on the tongue but also found on the palatal and esophageal mucosa

• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact

abnormal tongue morphology ( J:116740 )

• normal architecture is absent and the tissue is friable

digestive/alimentary system

abnormal oral mucosa morphology ( J:116740 )

• mild lymphocytic infiltration in the submucosa

oral leukoplakia ( J:116740 )

• primarily on the tongue but also found on the palatal and esophageal mucosa

• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact

abnormal tongue morphology ( J:116740 )

• normal architecture is absent and the tissue is friable

growth/size/body

abnormal oral mucosa morphology ( J:116740 )

• mild lymphocytic infiltration in the submucosa

oral leukoplakia ( J:116740 )

• primarily on the tongue but also found on the palatal and esophageal mucosa

• mucosal thickening and cytolysis of the spinous layer within lesions; however, the basal cell layer is intact

abnormal tongue morphology ( J:116740 )

• normal architecture is absent and the tissue is friable

postnatal growth retardation ( J:116740 )

• runted and underdeveloped by 2 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
white sponge nevus		DOID:0050448	OMIM:PS193900	J:116740

Allelic Composition	Krt4^Bcc1/Krt4⁺
Genetic Background	C3HeB/FeJ-Krt4^Bcc1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt4^Bcc1 mutation (0 available); any Krt4 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

pigmentation

diluted coat color ( J:116740 )

• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black

• difference in coat color is most visible around 4 weeks of age

craniofacial

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

integument

diluted coat color ( J:116740 )

• bright coat color and light brown pigment in all hairs rather than the normal dark brown/black

• difference in coat color is most visible around 4 weeks of age

growth/size/body

oral leukoplakia ( J:116740 )

• on the tongue

• milder than in homozygous mice

abnormal tongue morphology ( J:116740 )

• thickened lingual mucosa with evidence of inter-papillar cytolysis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
white sponge nevus		DOID:0050448	OMIM:PS193900	J:116740

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