Phenotypes associated with this allele

• Allele Symbol: Pon2^Gt(XE661)Byg
• Allele Name: gene trap XE661, BayGenomics
• Allele ID: MGI:3695400
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pon2^Gt(XE661)Byg/Pon2^Gt(XE661)Byg	B6.129P2-Pon2^Gt(XE661)Byg	MGI:3695755

Genotype
MGI:3695755

hm1

• Allelic Composition: Pon2^Gt(XE661)Byg/Pon2^Gt(XE661)Byg
• Genetic Background: B6.129P2-Pon2^Gt(XE661)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating protein level ( J:116935 )

• decreased serum levels of APOB

abnormal cholesterol homeostasis ( J:116935 )

• the rate of production of VLDL is reduced; however, clearance of LDL is similar to wild-type

• LDL is more susceptible to oxidation, has higher monocyte chemotaxis-inducing activity, and induces higher levels of lipid hydroperoxides in macrophages

• HDL is more inflammatory and less able to protect against LDL-induced monocyte chemotactic activity

decreased circulating cholesterol level ( J:116935 )

• about 24% lower compared to wild-type mice after 15 weeks on a high fat, high cholesterol, cholate-containing diet

decreased circulating LDL cholesterol level ( J:116935 )

• VLDL/LDL is about 32% lower compared to wild-type mice after 15 weeks on a high fat, high cholesterol, cholate-containing diet

decreased circulating VLDL cholesterol level ( J:116935 )

• VLDL/LDL is about 32% lower compared to wild-type mice after 15 weeks on a high fat, high cholesterol, cholate-containing diet

abnormal enzyme/coenzyme activity ( J:116935 )

• on a high fat, high cholesterol, cholate-containing diet serum PON1 activity is about 26% lower than in wild-type mice

cardiovascular system

increased susceptibility to atherosclerosis ( J:116935 )

• despite lower VLDL/LDL levels, atheromatous lesions in the aorta are significantly larger, after 15 weeks on a high fat, high cholesterol, cholate-containing diet, compared to wild-type mice

cellular

abnormal macrophage chemotaxis ( J:116935 )

• significantly more macrophages are found in the aorta wall

oxidative stress ( J:116935 )

• signs of oxidative stress are increased in the liver and peritoneal macrophages

immune system

abnormal macrophage physiology ( J:116935 )

• enhanced pro-inflammatory activity compared to wild-type cells

abnormal macrophage chemotaxis ( J:116935 )

• significantly more macrophages are found in the aorta wall

increased susceptibility to bacterial infection ( J:116935 )

• treatment with LPS induces an exacerbated inflammatory response with higher levels of inflammatory cytokines (TNFA and IL-1B)

hematopoietic system

abnormal macrophage physiology ( J:116935 )

• enhanced pro-inflammatory activity compared to wild-type cells

abnormal macrophage chemotaxis ( J:116935 )

• significantly more macrophages are found in the aorta wall