Phenotypes associated with this allele

• Allele Symbol: Kcna5^tm1Hket
• Allele Name: targeted mutation 1, Helmut Kettenmann
• Allele ID: MGI:3694764
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcna5^tm1Hket/Kcna5^tm1Hket	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3696082

Genotype
MGI:3696082

hm1

• Allelic Composition: Kcna5^tm1Hket/Kcna5^tm1Hket
• Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal microglial cell morphology ( J:116545 )

• after axotomy of facial nucleus, density of microglia is slightly decreased in striatum of mutants

abnormal nervous system electrophysiology ( J:116545 )

• in response to LPS, conductance increases of membrane currents in mutant cells are much reduced compared to wild-type

decreased channel response intensity ( J:116545 )

cellular

abnormal cell proliferation ( J:116545 )

• after LPS treatment, microglial cells in culture do not show decreased proliferation like that shown in wild-type

homeostasis/metabolism

abnormal nitric oxide homeostasis ( J:116545 )

• nitric oxide (NO) release is complete absent in mutants treated with LPS

hematopoietic system

abnormal microglial cell morphology ( J:116545 )

• after axotomy of facial nucleus, density of microglia is slightly decreased in striatum of mutants

immune system

abnormal microglial cell morphology ( J:116545 )

• after axotomy of facial nucleus, density of microglia is slightly decreased in striatum of mutants