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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt71Mhdarco12
Martin Hrabe de Angelis reduced coat 12
MGI:3693873
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt71Mhdarco12/Krt71Mhdarco12 C3HeB/FeJ-Krt71Mhdarco12 MGI:3695038
ht2
 		Krt71Mhdarco12/Krt71+ C3HeB/FeJ-Krt71Mhdarco12 MGI:3695039


Genotype
MGI:3695038
hm1
Allelic
Composition		 Krt71Mhdarco12/Krt71Mhdarco12
Genetic
Background		 C3HeB/FeJ-Krt71Mhdarco12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt71Mhdarco12 mutation (1 available); any Krt71 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Phenotype of Krt71Mhdarco12/+ or Krt71Mhdarco12/Krt71Mhdarco12 and Krt71Mhdarco13/+ or Krt71Mhdarco13/Krt71Mhdarco13 mice.

integument
waved hair ( J:116206 )
• curl visible by P10
• becomes less pronounced by 3 months of age
abnormal hair follicle inner root sheath morphology ( J:116206 )
• irregular formation of Henle's and Huxley's layers
• areas of increased thickness in Henle's layer are associated with round structures
• intermediate keratin filaments in Henle's layer form large whorls with only very short linear filamentous structures




Genotype
MGI:3695039
ht2
Allelic
Composition		 Krt71Mhdarco12/Krt71+
Genetic
Background		 C3HeB/FeJ-Krt71Mhdarco12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt71Mhdarco12 mutation (1 available); any Krt71 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Phenotype of Krt71Mhdarco12/+ or Krt71Mhdarco12/Krt71Mhdarco12 and Krt71Mhdarco13/+ or Krt71Mhdarco13/Krt71Mhdarco13 mice.

integument
waved hair ( J:116206 )
• curl visible by P10
• becomes less pronounced by 3 months of age
abnormal hair follicle inner root sheath morphology ( J:116206 )
• irregular formation of Henle's and Huxley's layers
• areas of increased thickness in Henle's layer are associated with round structures
• intermediate keratin filaments in Henle's layer form large whorls with short lengths of linear intermediate filament bundles




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory