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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chaf1atm1Ger
targeted mutation 1, Matthieu Gerard
MGI:3693625
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chaf1atm1Ger/Chaf1atm1Ger involves: 129S2/SvPasCrl MGI:3695418


Genotype
MGI:3695418
hm1
Allelic
Composition		 Chaf1atm1Ger/Chaf1atm1Ger
Genetic
Background		 involves: 129S2/SvPasCrl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chaf1atm1Ger mutation (0 available); any Chaf1a mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, incomplete penetrance ( J:116133 )
• only 10% of embryos at E4 are homozygous

embryo
embryonic growth arrest ( J:116133 )
• all embryos arrest at the 8 - 32 cell stage

cellular
abnormal cell nucleus morphology ( J:116133 )
• chromocenters are absent and heterochromatin in 8 - 16 cell stage embryos appears diffuse within the nucleus




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory