Phenotypes associated with this allele

• Allele Symbol: Ercc2^tm1Jmch
• Allele Name: targeted mutation 1, James R Mitchell
• Allele ID: MGI:3693615
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ercc2^tm1Jmch/Ercc2^tm1Jmch	involves: 129P2/OlaHsd * C57BL/6	MGI:3696346
ht2	Ercc2^tm1Jmch/Ercc2^tm2(ERCC2)Jhjh	involves: 129P2/OlaHsd * C57BL/6	MGI:3696347

Genotype
MGI:3696346

hm1

• Allelic Composition: Ercc2^tm1Jmch/Ercc2^tm1Jmch
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:116054 )

• no homozygous embryos are found at E3.5

Genotype
MGI:3696347

ht2

• Allelic Composition: Ercc2^tm1Jmch/Ercc2^{tm2(ERCC2)Jhjh}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

mortality/aging ( J:116054 )

N • normal lifespan unlike Ercc2^{tm2(ERCC2)Jhjh} homozygotes

cellular

decreased cellular sensitivity to ultraviolet irradiation ( J:116054 )

• UV sensitivity is less than in Ercc2^{tm2(ERCC2)Jhjh} Ercc2^tm1Jhjh compound heterozygotes

• decrease in UV sensitivity is not as large as in Ercc2^{tm2(ERCC2)Jhjh} Ercc2^tm2Jmch compound heterozygotes

growth/size/body

growth/size/body region phenotype ( J:116054 )

N • full rescue of age-related cachexia that is seen in Ercc2^{tm2(ERCC2)Jhjh} homozygotes

integument

focal dorsal hair loss ( J:116054 )

• only seen during the first hair cycle and only locally on the back