Phenotypes associated with this allele
Allelic Composition |
Casktm1Sud/Casktm1Sud
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Genetic Background |
involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casktm1Sud mutation
(1 available);
any
Cask mutation
(14 available)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casktm1.1Sud mutation
(0 available);
any
Cask mutation
(14 available)
Casktm1Sud mutation
(1 available);
any
Cask mutation
(14 available)
Tg(Prm-cre)58Og mutation
(4 available)
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Cleft palate in Casktm1Sud/Casktm1.1Sud Tg(Prm-cre)580g/0 mice
mortality/aging
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• die within a few hours of birth
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craniofacial
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• observed in homozygotes with ~80% penetrance
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digestive/alimentary system
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• observed in homozygotes with ~80% penetrance
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nervous system
N |
• synapse formation and membrane properties of cultured neurons are not significantly different from wild-type neurons; vesicle pool sizes and evoked neurotransmitter release are similar in mutant and wild-type neurons
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• number of apoptotic neurons in thalamus is increased 3-fold compared to controls
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• excitatory spontaneous mini events show 2-fold increase in frequency in cultured neurons, while inhibitory minifrequency is decreased ~1.4 fold
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respiratory system
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• plethysmography of newborns shows severe postnatal respiratory failure
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cellular
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• number of apoptotic neurons in thalamus is increased 3-fold compared to controls
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growth/size/body
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• observed in homozygotes with ~80% penetrance
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