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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sall4tm2.1Tre
targeted mutation 2.1, Mathias Treier
MGI:3693080
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sall4tm2.1Tre/Sall4tm2.1Tre involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3693089
ht2
 		Sall4tm1Tre/Sall4tm2.1Tre involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 MGI:3693084
cn3
 		Sall4tm2Tre/Sall4tm2.1Tre
Edil3Tg(Sox2-cre)1Amc/Edil3+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1 MGI:3693081


Genotype
MGI:3693089
hm1
Allelic
Composition		 Sall4tm2.1Tre/Sall4tm2.1Tre
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4tm2.1Tre mutation (0 available); any Sall4 mutation (145 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:115635 )
• no prestreak embryos are found; empty implantations are regularly observed




Genotype
MGI:3693084
ht2
Allelic
Composition		 Sall4tm1Tre/Sall4tm2.1Tre
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sall4tm1Tre mutation (0 available); any Sall4 mutation (145 available)
Sall4tm2.1Tre mutation (0 available); any Sall4 mutation (145 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality between implantation and somite formation, complete penetrance ( J:115635 )
• no prestreak embryos are found; empty implantations are regularly observed




Genotype
MGI:3693081
cn3
Allelic
Composition		 Sall4tm2Tre/Sall4tm2.1Tre
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation (5 available); any Edil3 mutation (44 available)
Sall4tm2.1Tre mutation (0 available); any Sall4 mutation (145 available)
Sall4tm2Tre mutation (0 available); any Sall4 mutation (145 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
embryonic growth arrest ( J:115635 )
• embryo development is arrested at the late primitive streak stage, before somite development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory