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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfaptm2Mes
targeted mutation 2, Albee Messing
MGI:3692741
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gfaptm2Mes/Gfaptm2Mes involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692744
ht2
 		Gfaptm2Mes/Gfap+ involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692745
cx3
 		Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Gfaptm2Mes/Gfap+ 		involves: 129S4/SvJae * 129S7/SvEvBrd MGI:3850527
cx4
 		Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0 		involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N MGI:3850532
cx5
 		Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692746
cx6
 		Gfaptm2Mes/Gfap+
Tg(GFAP-CRYAB)141.6Mes/0 		involves: 129S7/SvEvBrd * FVB/N MGI:3850534
cx7
 		Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0 		involves: 129S7/SvEvBrd * FVB/N MGI:3850536


Genotype
MGI:3692744
hm1
Allelic
Composition		 Gfaptm2Mes/Gfaptm2Mes
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:114689 )
• weigh less than wild-type or heterozygotes

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop more Rosenthal fibers than heterozygotes




Genotype
MGI:3692745
ht2
Allelic
Composition		 Gfaptm2Mes/Gfap+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:114689 )
• exhibit a more significant difference in body weight than heterozygous Gfaptm1Hgmn mutants

nervous system
increased susceptibility to pharmacologically induced seizures ( J:114689 )
• show increased sensitivity to kainate induced-seizures, with 50% compared to 10% of wild-type developing severe seizures and increased lethality over wild-type
abnormal brain iron level ( J:114689 )
• exhibit iron accumulation in the hypertrophic astrocytes of the corpus callosum
abnormal astrocyte morphology ( J:114689 )
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit more Rosenthal fibers than seen in heterozygous Gfaptm1Hgmn mutants
• Rosenthal fibers are apparent at the pial surfaces of the brainstem and ventral midbrain and forebrain as early as P7
• astrocytes appear hypertrophic in the above regions at 3 months of age

homeostasis/metabolism
abnormal brain iron level ( J:114689 )
• exhibit iron accumulation in the hypertrophic astrocytes of the corpus callosum

behavior/neurological
increased susceptibility to pharmacologically induced seizures ( J:114689 )
• show increased sensitivity to kainate induced-seizures, with 50% compared to 10% of wild-type developing severe seizures and increased lethality over wild-type

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:114689




Genotype
MGI:3850527
cx3
Allelic
Composition		 Del(9Hspb2-Cryab)1Wawr/Del(9Hspb2-Cryab)1Wawr
Gfaptm2Mes/Gfap+
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(9Hspb2-Cryab)1Wawr mutation (0 available); any Del(9Hspb2-Cryab)1Wawr mutation (0 available)
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:146191 )
N
• mice remain viable in Cryab-null background in contrast to Cryab-null, GFAP-overexpressing mice




Genotype
MGI:3850532
cx4
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background		 involves: 129S4/SvJae * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
Tg(GFAP)10Mes mutation (0 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:146191 )
N
• all animals survive compared to Tg(GFAP-Cryab)141.6Mes-positive double mutants which die around 30 days of age

nervous system
abnormal hippocampus morphology ( J:146191 )
• Rosenthal fibers are observed, but numbers are significantly less than in Gfaptm2Hgmn/+/Tg(GFAP)10Mes animals; both soluble and insoluble GFAP levels are reduced




Genotype
MGI:3692746
cx5
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
Tg(GFAP)10Mes mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:114689 )
• almost all die at around 30 days of age

nervous system
seizures ( J:114689 )
• two mutants exhibit seizure-like episodes before death
abnormal astrocyte morphology ( J:114689 )
• at 24 days of age, exhibit increased Rosenthal fiber formation and higher levels of insoluble Gfap than either single mutant
• astrocytes are hypertrophied in the regions of brain that normally show high levels of Gfap expression

behavior/neurological
seizures ( J:114689 )
• two mutants exhibit seizure-like episodes before death

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:114689




Genotype
MGI:3850534
cx6
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP-CRYAB)141.6Mes/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
Tg(GFAP-CRYAB)141.6Mes mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell physiology ( J:146191 )
• the stress response is reduced by 90% at 6 weeks compared to the stress response is reduced by 90% at 6 weeks compared Gfaptm2Hgmn/+/+ mice




Genotype
MGI:3850536
cx7
Allelic
Composition		 Gfaptm2Mes/Gfap+
Tg(GFAP)10Mes/0
Genetic
Background		 involves: 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm2Mes mutation (2 available); any Gfap mutation (47 available)
Tg(GFAP)10Mes mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:146191 )
• all animals die by under 50 days of age (most die around 30 days)

nervous system
abnormal hippocampus morphology ( J:146191 )
• Rosenthal fiber formation is observed

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:146191




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory