All Phenotypes Ttc7<fsn-Jic> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ttc7^fsn-Jic/Ttc7^fsn-Jic	B6.INT-Ttc7^fsn-Jic	MGI:3692771
hm2	Ttc7^fsn-Jic/Ttc7^fsn-Jic	C3.INT-Ttc7^fsn-Jic	MGI:3692773
hm3	Ttc7^fsn-Jic/Ttc7^fsn-Jic	CBy.INT-Ttc7^fsn-Jic	MGI:3692772
ht4	Ttc7^fsn/Ttc7^fsn-Jic	involves: A/J * BALB/c * C57BL/6 * INT	MGI:3692890

Allelic Composition	Ttc7^fsn-Jic/Ttc7^fsn-Jic
Genetic Background	B6.INT-Ttc7^fsn-Jic

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttc7^fsn-Jic mutation (0 available); any Ttc7 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:115742 )

• Background Sensitivity: mean lifespan of affected mice is 3.5 days

hematopoietic system

anemia ( J:115742 )

increased fetal derived definitive erythrocyte cell number ( J:115742 )

• in peripheral blood, number of fetal nucleated red blood cells (FNRBC) decreased to E14.5, then increase gradually up to E17.5, while in controls, FNRBC count decreases gradually to E17.5; numbers of FNRBCs is 20-fold higher than in controls at E17.5

pigmentation

abnormal tail pigmentation ( J:115742 )

• tails of homozygotes are lined

limbs/digits/tail

abnormal tail pigmentation ( J:115742 )

• tails of homozygotes are lined

integument

integument phenotype ( J:115742 )

N	• skin is normal at embryonic stages

pallor ( J:115742 )

• homozygotes have pale skin

abnormal tail pigmentation ( J:115742 )

• tails of homozygotes are lined

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:115742 )

• Background Sensitivity: mean lifespan of affected mice is 11.6 days

growth/size/body

decreased body weight ( J:115742 )

• body weights are lower than wild-type controls

increased spleen weight ( J:115742 )

• at 10 days of age, spleen weight to body weight ratio is significantly higher than in wild-type (spleen weight = 32.8 mg vs 46.9 in controls)

hematopoietic system

decreased thymus weight ( J:115742 )

• at 10 days of age, thymus weight to body weight ratio is significantly lower than in wild-type (mutant thymus = 4.1 mg vs 46.9 mg in control)

increased spleen weight ( J:115742 )

• at 10 days of age, spleen weight to body weight ratio is significantly higher than in wild-type (spleen weight = 32.8 mg vs 46.9 in controls)

extramedullary hematopoiesis ( J:115742 )

• marked extramedullary hematopoiesis is observed in spleen and liver

anemia ( J:115742 )

• mice display severe anemia

abnormal erythrocyte morphology ( J:115742 )

• in neonates, a large number of red blood cells show abnormalities such as dacrocytes and acanthocytes

low mean erythrocyte cell number ( J:115742 )

• numbers of red blood cells is significantly decreased compared to wild-type at 10 days after birth

decreased hematocrit ( J:115742 )

• values are much lower than in normal mice

increased nucleated erythrocyte cell number ( J:115742 )

• number of nucleated cells is 35 times higher than in controls

acanthocytosis ( J:115742 )

• in neonates

dacryocytosis ( J:115742 )

• in neonates

thrombocytosis ( J:115742 )

• number of platelets is significantly increased compared to controls

increased spleen red pulp amount ( J:115742 )

• red pulp is increased in mutant spleens

decreased spleen white pulp amount ( J:115742 )

• spleens of mutants display markedly reduced white pulp

immune system

decreased thymus weight ( J:115742 )

• at 10 days of age, thymus weight to body weight ratio is significantly lower than in wild-type (mutant thymus = 4.1 mg vs 46.9 mg in control)

increased spleen weight ( J:115742 )

• at 10 days of age, spleen weight to body weight ratio is significantly higher than in wild-type (spleen weight = 32.8 mg vs 46.9 in controls)

increased spleen red pulp amount ( J:115742 )

• red pulp is increased in mutant spleens

decreased spleen white pulp amount ( J:115742 )

• spleens of mutants display markedly reduced white pulp

liver inflammation ( J:115742 )

• homozygous livers show hepatitis with inflammatory cell infiltrate

cardiovascular system

decreased heart weight ( J:115742 )

• at 10 days of age, heart weight to body weight ratio is significantly higher than in wild-type (heart weight = 38.9 mg vs 49.9 mg in controls)

liver/biliary system

liver inflammation ( J:115742 )

• homozygous livers show hepatitis with inflammatory cell infiltrate

liver hypoplasia ( J:115742 )

• cellularity of liver cortex is markedly reduced compared to control

pale liver ( J:115742 )

• liver is paler than in control

renal/urinary system

pale kidney ( J:115742 )

• kidney is paler than in control

integument

sparse hair ( J:115742 )

• sparse pelage is often seen in homozygotes

mixed cellular infiltration to dermis ( J:115742 )

• neutrophilic infiltration in epidermis with prominent dermal inflammatory infiltrates is observed in neonates

hyperkeratosis ( J:115742 )

• in affected neonates

parakeratosis ( J:115742 )

• focal parakeratosis is seen in neonates

acanthosis ( J:115742 )

• neonates show marked acanthosis

abnormal skin condition ( J:115742 )

• homozygotes have papulosquamous skin lesions

endocrine/exocrine glands

decreased thymus weight ( J:115742 )

• at 10 days of age, thymus weight to body weight ratio is significantly lower than in wild-type (mutant thymus = 4.1 mg vs 46.9 mg in control)

Allelic Composition	Ttc7^fsn-Jic/Ttc7^fsn-Jic
Genetic Background	CBy.INT-Ttc7^fsn-Jic

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttc7^fsn-Jic mutation (0 available); any Ttc7 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:115742 )

• Background Sensitivity: mean lifespan of affected mice is 7.7 days

hematopoietic system

anemia ( J:115742 )

• homozygotes are severely anemic

integument

scaly skin ( J:115742 )

• skin of homozygotes is scaly

abnormal skin condition ( J:115742 )

• homozygotes have papulosquamous skin

Allelic Composition	Ttc7^fsn/Ttc7^fsn-Jic
Genetic Background	involves: A/J * BALB/c * C57BL/6 * INT

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ttc7^fsn mutation (1 available); any Ttc7 mutation (43 available)
Ttc7^fsn-Jic mutation (0 available); any Ttc7 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:115742 )

• mean life span of homozygotes is 67.2 days

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23