Phenotypes associated with this allele

• Allele Symbol: Dgkd^tm1Mtop
• Allele Name: targeted mutation 1, Matthew K Topham
• Allele ID: MGI:3692387
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dgkd^tm1Mtop/Dgkd^tm1Mtop	involves: C57BL/6J	MGI:3697237

Genotype
MGI:3697237

hm1

• Allelic Composition: Dgkd^tm1Mtop/Dgkd^tm1Mtop
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphology of Dgkd^tm1Mtop/Dgkd^tm1Mtop mice

mortality/aging

neonatal lethality, complete penetrance ( J:115297 )

• newborns develop respiratory distress and die within 24 hours of birth

growth/size/body

decreased birth weight ( J:115297 )

• at birth, mice weigh 1.1 grams compared to 1.39 grams for wild-type

decreased fetal size ( J:115297 )

• most fetuses are smaller than wild-type littermates

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:115297 )

• protein kinase C (PKC) activity in mutant lungs and epidermis is higher than in controls

respiratory system

respiratory distress ( J:115297 )

vision/eye

eyelids open at birth ( J:115297 )

• at E17.5 and at birth, all homozygotes have opened eyelids

integument

abnormal skin physiology ( J:115297 )

• EGFR levels in all layers of the epidermis are reduced, most significantly in the basal layer