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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dgkdtm1Mtop
targeted mutation 1, Matthew K Topham
MGI:3692387
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dgkdtm1Mtop/Dgkdtm1Mtop involves: C57BL/6J MGI:3697237


Genotype
MGI:3697237
hm1
Allelic
Composition
Dgkdtm1Mtop/Dgkdtm1Mtop
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dgkdtm1Mtop mutation (0 available); any Dgkd mutation (39 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Morphology of Dgkdtm1Mtop/Dgkdtm1Mtop mice

mortality/aging
• newborns develop respiratory distress and die within 24 hours of birth

growth/size/body
• at birth, mice weigh 1.1 grams compared to 1.39 grams for wild-type
• most fetuses are smaller than wild-type littermates

homeostasis/metabolism
• protein kinase C (PKC) activity in mutant lungs and epidermis is higher than in controls

respiratory system

vision/eye
• at E17.5 and at birth, all homozygotes have opened eyelids

integument
• EGFR levels in all layers of the epidermis are reduced, most significantly in the basal layer





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory