About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kcptm1Ysas
targeted mutation 1, Yoshiki Sasai
MGI:3691856
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kcptm1Ysas/Kcptm1Ysas involves: C57BL/6 * CBA MGI:3692273
cx2
 		Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcptm1Ysas 		involves: C57BL/6 * CBA MGI:3692277
cx3
 		Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcp+ 		involves: C57BL/6 * CBA MGI:3692281


Genotype
MGI:3692273
hm1
Allelic
Composition		 Kcptm1Ysas/Kcptm1Ysas
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115338 )
• homozygotes are viable and fertile and exhibit no gross structural defects, including in kidney formation




Genotype
MGI:3692277
cx2
Allelic
Composition		 Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcptm1Ysas
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpertm1Ysas mutation (1 available); any Bmper mutation (47 available)
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased renal glomerulus number ( J:115338 )
• exhibit a further reduction in the glomerulus number compared to single Bmper homozygotes
abnormal kidney corticomedullary boundary morphology ( J:115338 )
• exhibit a strong disorganization of the cortex-medullar arrangement with no clear border in between
small kidney ( J:115338 )
• exhibit a further reduction in kidney size than seen in single Bmper homozygotes

skeleton
abnormal skeleton morphology ( J:115338 )
• exhibit skeletal phenotypes similar to that seen in single homozygous Bmper mutants that are not enhanced by the deletion of Crim2




Genotype
MGI:3692281
cx3
Allelic
Composition		 Bmpertm1Ysas/Bmpertm1Ysas
Kcptm1Ysas/Kcp+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpertm1Ysas mutation (1 available); any Bmper mutation (47 available)
Kcptm1Ysas mutation (1 available); any Kcp mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
decreased renal glomerulus number ( J:115338 )
• exhibit a further reduction in the glomerulus number compared to single Bmper homozygotes
abnormal kidney corticomedullary boundary morphology ( J:115338 )
• exhibit a strong disorganization of the cortex-medullar arrangement with no clear border in between
small kidney ( J:115338 )
• exhibit a further reduction in kidney size than seen in single Bmper homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory