Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4tm1(cre)Xz mutation
(2 available);
any
Slc6a4 mutation
(51 available)
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mortality/aging
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• 75% of mice die with the first week after birth
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cardiovascular system
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• at E18.5, mice exhibit an increase in collagen accumulation in the myocardium and valvular and perivascular regions of the heart unlike wild-type mice
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Allelic Composition |
Slc6a4tm1(cre)Xz/Slc6a4+
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Genetic Background |
involves: 129S1/Sv * C57BL/6 * SJL |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a4tm1(cre)Xz mutation
(2 available);
any
Slc6a4 mutation
(51 available)
|
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normal phenotype
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• mice are viable and fertile
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc18a2tm1.1Bgir mutation
(0 available);
any
Slc18a2 mutation
(29 available)
Slc6a4tm1(cre)Xz mutation
(2 available);
any
Slc6a4 mutation
(51 available)
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mortality/aging
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• some mice die between P1 and P30
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behavior/neurological
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• in a tail suspension test, mice exhibit an increase in active defense behavior indicated by increased time spent struggling to escape and decreased immobilization compared with wild-type mice
• in response to aversive ultrasonic stimulus, mice exhibit a large increase in behavioral reactivity with less freezing compared with wild-type mice
• however, mice treated with pargyline exhibit normal flight responses in response to ultrasonic stimulus
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• in a novelty-suppressed feeding test, mice exhibit faster initiation of feeding compared with wild-type mice
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• in an elevated plus maze
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homeostasis/metabolism
nervous system
N |
• 5-HT raphe neurons develop normally
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