All Phenotypes Scn5a<tm1(SCN5A)Rdn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scn5a^{tm1(SCN5A)Rdn}
targeted mutation 1, Dan M Roden
MGI:3691483

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn5a^{tm1(SCN5A)Rdn}/Scn5a^{tm1(SCN5A)Rdn}	involves: 129S6/SvEvTac	MGI:3692322
ht2	Scn5a^{tm1(SCN5A)Rdn}/Scn5a^{tm3(SCN5A*)Rdn}	involves: 129S6/SvEvTac	MGI:5445936

Allelic Composition	Scn5a^{tm1(SCN5A)Rdn}/Scn5a^{tm1(SCN5A)Rdn}
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5a^{tm1(SCN5A)Rdn} mutation (1 available); any Scn5a mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:115269 )

• homozygotes are viable, exhibit no obvious morphological abnormalities and are fertile, and have normal sodium channel function as shown by electrocardiograms, ventricular myocyte action potentials, and ventricular myocyte sodium currents

Allelic Composition	Scn5a^{tm1(SCN5A)Rdn}/Scn5a^{tm3(SCN5A*)Rdn}
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn5a^{tm1(SCN5A)Rdn} mutation (1 available); any Scn5a mutation (104 available)
Scn5a^{tm3(SCN5A*)Rdn} mutation (1 available); any Scn5a mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

dilated heart left ventricle ( J:189389 )

• intermediate at 12 weeks

dilated cardiomyopathy ( J:189389 )

decreased cardiac muscle contractility ( J:189389 )

• intermediate at 12 weeks

decreased heart rate ( J:189389 )

• intermediate at 3 weeks

prolonged P wave ( J:189389 )

• intermediate at 3 and 12 weeks

prolonged QRS complex duration ( J:189389 )

• intermediate at 3 weeks

muscle

dilated cardiomyopathy ( J:189389 )

decreased cardiac muscle contractility ( J:189389 )

• intermediate at 12 weeks

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1E		DOID:0110433	OMIM:601154	J:189389

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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