About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nit1tm1.1Hbn
targeted mutation 1, Kay Huebner
MGI:3691199
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nit1tm1.1Hbn/Nit1tm1.1Hbn involves: 129X1/SvJ * C57BL/6 MGI:3691214
ht2
 		Nit1tm1Hbn/Nit1tm1.1Hbn involves: 129X1/SvJ * C57BL/6 MGI:3691216


Genotype
MGI:3691214
hm1
Allelic
Composition		 Nit1tm1.1Hbn/Nit1tm1.1Hbn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1.1Hbn mutation (0 available); any Nit1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:115052 )
• mutation does not affect embryogenesis, and growth and development are normal; mice did not develop spontaneous tumors during a year of observation

neoplasm
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice




Genotype
MGI:3691216
ht2
Allelic
Composition		 Nit1tm1Hbn/Nit1tm1.1Hbn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nit1tm1.1Hbn mutation (0 available); any Nit1 mutation (15 available)
Nit1tm1Hbn mutation (0 available); any Nit1 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice

homeostasis/metabolism
increased incidence of tumors by chemical induction ( J:115052 )
• mice receiving 6 intragastric doses of N-nitrosomethylbenzylamine (NMBA) over 3 weeks show increased incidence of forestomach papillomas and dysplasias (carcinomas in situ) compared to controls; number of papillomas and dysplasias is ~equivalent to numbers in Fhit-deficient mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory