Phenotypes associated with this allele

• Allele Symbol: Maea^Gt(XG702)Byg
• Allele Name: gene trap XG702, BayGenomics
• Allele ID: MGI:3691058
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Maea^Gt(XG702)Byg/Maea^Gt(XG702)Byg	involves: 129P2/OlaHsd * C57BL/6J	MGI:3691230

Genotype
MGI:3691230

hm1

• Allelic Composition: Maea^Gt(XG702)Byg/Maea^Gt(XG702)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:114865 )

• no homozygotes are born but Mendelian numbers are present through E19.5

growth/size/body

decreased fetal size ( J:114865 )

• at E14.5 onward, null mice are smaller than littermates

hematopoietic system

abnormal erythropoiesis ( J:114865 )

• at E15.5, mutant livers contain predominantly large immature erythroblasts with few enucleated erythrocytes

increased nucleated erythrocyte cell number ( J:114865 )

• at E14.5-16.5, null fetuses contain mostly nucleated erythrocytes; at E14.5, peripheral blood in wild-type fetuses contains ~25% nucleated erythrocytes and only 5% at E16.5 compared to 65-70% in null fetuses

• in cluture with macrophages, null fibroblasts show an enucleation defect; in wild-type cultures, ~40% of cells are enucleated compared to ~10% in mutant cultures

decreased macrophage cell number ( J:114865 )

• mutant livers contain only 25-30% of control macrophage numbers

immune system

decreased macrophage cell number ( J:114865 )

• mutant livers contain only 25-30% of control macrophage numbers

integument

pallor ( J:114865 )

• from E14.5 on, homozygotes are pale in appearance