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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il2rgtm1Krf
targeted mutation 1, Paul Krimpenfort
MGI:3690461
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Il2rgtm1Krf/Il2rgtm1Krf either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N) MGI:3698151
cx2
 		Il2rgtm1Krf/Il2rgtm1Krf
Tg(BCL2/IGH)1Tjd/0 		either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N) MGI:3698154
cx3
 		Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0 		either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N) MGI:3698152


Genotype
MGI:3698151
hm1
Allelic
Composition		 Il2rgtm1Krf/Il2rgtm1Krf
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation (0 available); any Il2rg mutation (168 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice

hematopoietic system
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice




Genotype
MGI:3698154
cx2
Allelic
Composition		 Il2rgtm1Krf/Il2rgtm1Krf
Tg(BCL2/IGH)1Tjd/0
Genetic
Background		 either: (involves: 129P2/OlaHsd * C3H/He * C57BL/6) or (involves: 129P2/OlaHsd * C3H/He * C57BL/6 * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation (0 available); any Il2rg mutation (168 available)
Tg(BCL2/IGH)1Tjd mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice

hematopoietic system
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• mice have about 10-fold fewer thymocytes compared to wild-type mice




Genotype
MGI:3698152
cx3
Allelic
Composition		 Il2rgtm1Krf/Il2rgtm1Krf
Tg(Igh-Pim1)1Brn/0
Genetic
Background		 either: (involves: 129P2/OlaHsd * C57BL/6 * CBA) or (involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il2rgtm1Krf mutation (0 available); any Il2rg mutation (168 available)
Tg(Igh-Pim1)1Brn mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

hematopoietic system
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)

endocrine/exocrine glands
decreased thymocyte number ( J:114561 )
• thymocyte number is increased to 70-100 x 106 cells compared to 10-25 x 106 cells in null mice without the transgene but, the number is still decreased relative to wild-type mice (200-300 x 106 cells)




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory