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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gfaptm3Mes
targeted mutation 3, Albee Messing
MGI:3690430
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gfaptm3Mes/Gfaptm3Mes involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692742
ht2
 		Gfaptm3Mes/Gfap+ involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N MGI:3692743


Genotype
MGI:3692742
hm1
Allelic
Composition		 Gfaptm3Mes/Gfaptm3Mes
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm3Mes mutation (1 available); any Gfap mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:114689 )
• weigh less than wild-type or heterozygotes

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop more Rosenthal fibers than heterozygotes

cellular
abnormal astrocyte morphology ( J:114689 )
• develop more Rosenthal fibers than heterozygotes




Genotype
MGI:3692743
ht2
Allelic
Composition		 Gfaptm3Mes/Gfap+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfaptm3Mes mutation (1 available); any Gfap mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body size ( J:114689 )

nervous system
abnormal astrocyte morphology ( J:114689 )
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

cellular
abnormal astrocyte morphology ( J:114689 )
• develop Rosenthal fibers, especially within the hippocampus, olfactory bulb, corpus callosum, and rostral extension, as well as in subpial, perivascular and periventricular regions
• exhibit fewer Rosenthal fibers than seen in heterozygous Gfaptm2Hgmn mutants

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Alexander disease DOID:4252 OMIM:203450
 J:114689




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory