Phenotypes associated with this allele

• Allele Symbol: Erbb3^tm1Squ
• Allele Name: targeted mutation 1, Shimian Qu
• Allele ID: MGI:3690339
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Erbb3^tm1Squ/Erbb3^tm1Squ Tg(EIIa-cre)C5379Lmgd/0	involves: 129S6/SvEvTac * FVB/N	MGI:3691285
cn2	Erbb3^tm1Squ/Erbb3^tm1Squ Tg(MMTV-cre)7Mul/0	involves: 129S6/SvEvTac * FVB/N	MGI:3691287

Genotype
MGI:3691285

cn1

• Allelic Composition: Erbb3^tm1Squ/Erbb3^tm1Squ; Tg(EIIa-cre)C5379Lmgd/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:114524 )

• normal numbers of homozygous embryos are found at E12.5 but number of viable embryos is severely reduced at E13.5

nervous system

absent Schwann cells ( J:114524 )

• there is a lack of Schwann cells and Schwann cell precursors in DRGs

abnormal dorsal root ganglion morphology ( J:114524 )

• there is a lack of Schwann cells and Schwann cell precursors in DRGs

cardiovascular system

abnormal atrioventricular valve morphology ( J:114524 )

• mutants exhibit defects in the atrioventricular valves

cellular

absent Schwann cells ( J:114524 )

• there is a lack of Schwann cells and Schwann cell precursors in DRGs

Genotype
MGI:3691287

cn2

• Allelic Composition: Erbb3^tm1Squ/Erbb3^tm1Squ; Tg(MMTV-cre)7Mul/0
• Genetic Background: involves: 129S6/SvEvTac * FVB/N

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:114524 )

♀ • ductal density is lower in 4-8 week-old virgin females

♀ • there are fewer end branches and terminal buds in mammary gland ductal system

integument

abnormal branching of the mammary ductal tree ( J:114524 )

♀ • ductal density is lower in 4-8 week-old virgin females

♀ • there are fewer end branches and terminal buds in mammary gland ductal system