Phenotypes associated with this allele

• Allele Symbol: Retnlb^tm1Gdw
• Allele Name: targeted mutation 1, Gary D Wu
• Allele ID: MGI:3690334
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Retnlb^tm1Gdw/Retnlb^tm1Gdw	involves: 129S/SvEv * C57BL/6	MGI:3697623

Genotype
MGI:3697623

hm1

• Allelic Composition: Retnlb^tm1Gdw/Retnlb^tm1Gdw
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Retnlb^tm1Gdw/Retnlb^tm1Gdw mice are less susceptible than wild type to dextran sodium sulfate-induced colitis

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:114507 )

• exhibit increased survival compared to wild-type when colonic injury and colitis is induced by DSS

homeostasis/metabolism

decreased susceptibility to injury ( J:114507 )

• in a dextran sodium sulfate (DSS) model of murine colonic injury, homozygotes lose less weight than wild-type, show a delay in the onset of intestinal bleeding and the development of loose stool and colitis, and increased survival, indicating protection from induced colitis

digestive/alimentary system

decreased susceptibility to induced colitis ( J:114507 )

• exhibit reduced severity of colitis in a dextran sodium sulfate model of murine colonic injury compared to wild-type

immune system

decreased inflammatory response ( J:114507 )

• after DSS treatment to induce colonic injury, homozygotes show less pronounced inflammatory infiltrate in distal colons than in wild-type, without any alteration in the proportion of either macrophages or granulocytes

decreased susceptibility to induced colitis ( J:114507 )

• exhibit reduced severity of colitis in a dextran sodium sulfate model of murine colonic injury compared to wild-type