Phenotypes associated with this allele

• Allele Symbol: Scarb1^tm1.1Thh
• Allele Name: targeted mutation 1.1, Thierry Huby
• Allele ID: MGI:3690317
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scarb1^tm1.1Thh/Scarb1^tm1.1Thh	B6.129X1-Scarb1^tm1.1Thh	MGI:3697678

Genotype
MGI:3697678

hm1

• Allelic Composition: Scarb1^tm1.1Thh/Scarb1^tm1.1Thh
• Genetic Background: B6.129X1-Scarb1^tm1.1Thh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:114663 )

• elevation in plasma total cholesterol that is associated with more than 3-fold increase in free cholesterol

• high increase in plasma free cholesterol/plasma total cholesterol ratio

• develop severe hypercholesterolemia on an atherogenic diet due to an accumulation of free cholesterol-rich, VLDL-sized particles

• hepatic content of free and esterified cholesterol is normal

increased circulating HDL cholesterol level ( J:114663 )

• marked elevation of HDL cholesterol with abnormally large HDL particles

increased circulating interleukin-6 level ( J:114663 )

• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type

cardiovascular system

increased susceptibility to atherosclerosis ( J:114663 )

• atherosclerosis is enhanced 48-fold compared to controls, when fed an atherogenic (high-fat, high-cholesterol, and cholic acid-containing) diet

reproductive system

female infertility ( J:114663 )

♀ • females are sterile when fed a normal chow diet, however fertility is restored when diet is supplemented with a lipid-lowering drug, probucol

immune system

increased circulating interleukin-6 level ( J:114663 )

• on an atherogenic diet, IL-6 plasma levels are 10.8-fold greater than in wild-type