Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln3tm1Fong mutation
(0 available);
any
Egln3 mutation
(24 available)
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muscle
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N |
• after 7 days ischemia induced by femoral artery ligation, mice display extensive muscle necrosis, similar in extent to wild-type animals
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cardiovascular system
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N |
• no abnormalities in vessel number or size are detected unlike mice with conditional deletion of Egln1
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hematopoietic system
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N |
• unlike Egln2tm1Fong Egln3 tm1Fong double homozygotes, single homozygotes do not display any hematological abnormalities
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln3tm1Fong mutation
(0 available);
any
Egln3 mutation
(24 available)
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embryo
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N |
• no placental defects are detected
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cardiovascular system
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N |
• no cardiac or vascular developmental defects are detected
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egln2tm1Fong mutation
(0 available);
any
Egln2 mutation
(18 available)
Egln3tm1Fong mutation
(0 available);
any
Egln3 mutation
(24 available)
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hematopoietic system
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• 2.4-fold increase in the number of hematopoietic stem cells in bone marrow derived cells
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• 4.3- and 3.6-fold increase in the number of erythroid progenitors in the spleen and liver, respectively, although no increase in hematopoietic activity is detected in a methylcellulose colony-forming activity
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• increase in red but not white cell counts in peripheral blood samples
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• in peripheral blood samples
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• in peripheral blood samples
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• increase in the number of erythroid progenitor cells
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liver/biliary system
craniofacial
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• reddened snout especially in the area under the nostrils
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limbs/digits/tail
reproductive system
immune system
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• increase in the number of erythroid progenitor cells
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integument
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• reddened paws and snout
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growth/size/body
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• reddened snout especially in the area under the nostrils
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Analysis Tools