All Phenotypes Akt2<tm1Hem> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akt2^tm1Hem/Akt2^tm1Hem	involves: 129P2/OlaHsd	MGI:5429853
hm2	Akt2^tm1Hem/Akt2^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691593
cx3	Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691594
cx4	Akt1^tm1Hem/Akt1^tm1Hem Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691595
cx5	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem	involves: 129P2/OlaHsd * C57BL/6	MGI:3691596

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal ovary morphology ( J:185012 )

• hyperplasia of spindle-like stromal cells

• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function

decreased corpora lutea number ( J:185012 )

• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling

increased theca cell number ( J:185012 )

• ovarian cysts are characterized by thecal-interstitial hyperplasia

ovary cyst ( J:185012 )

• 80% of females develop severe ovarian cysts; cysts increase in size with age

• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen

• young females treated with leutinizing hormone alone or with GnRHAnt (to induce cyst formation) show an approximate 3-fold increase in cystic area in the ovaries compared to treated wild-type mice, however hyperinsulinemia is not seen in these mutants

homeostasis/metabolism

increased circulating testosterone level ( J:185012 )

• aged females exhibit a 2-fold increase in serum testosterone levels

reproductive system

abnormal ovary morphology ( J:185012 )

• hyperplasia of spindle-like stromal cells

• while aged females develop ovarian cysts, young females display normal steroidogenic and reproductive function

decreased corpora lutea number ( J:185012 )

• cysts show a severe reduction or lack of corpus luteum in aged ovaries, suggesting a cessation of estrous cycling

increased theca cell number ( J:185012 )

• ovarian cysts are characterized by thecal-interstitial hyperplasia

ovary cyst ( J:185012 )

• 80% of females develop severe ovarian cysts; cysts increase in size with age

• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen

growth/size/body

ovary cyst ( J:185012 )

• 80% of females develop severe ovarian cysts; cysts increase in size with age

• ovarian cysts show increased steroidogenic capacity as indicated by an increase in the activation of steroidogenic signaling and the presence of lipids in the cells surrounding the cystic lumen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
polycystic ovary syndrome		DOID:11612	OMIM:184700	J:185012

Allelic Composition	Akt2^tm1Hem/Akt2^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Hem mutation (0 available); any Akt2 mutation (51 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

hyperglycemia ( J:114675 )

• observed under both random feeding and fasting conditions

increased circulating insulin level ( J:114675 )

• plasma insulin levels were significantly higher under random feeding condition

impaired glucose tolerance ( J:114675 )

• susceptibility to glucose intolerance in male

insulin resistance ( J:114675 )

• reduced insulin sensitivity in both male and female mice

Allelic Composition	Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt2^tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3^tm1Hem mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:114675 )

• viable and fertile and showed no obvious abnormalities, except for their smaller size

decreased body weight ( J:114675 )

• in male an average decrease in body weight of 25% persisted throughout life

• in female an average decrease in body weight of 14% from the forth week of age onward

nervous system

decreased brain weight ( J:114675 )

• approximately 35% reduction in brain weight of 3-month old mice

endocrine/exocrine glands

abnormal testis morphology ( J:114675 )

• showed an approximately 1.5 fold increase in apoptotic cells in testis

decreased testis weight ( J:114675 )

• approximately 40% reduction in testis weight of 3-month old mice

reproductive system

abnormal testis morphology ( J:114675 )

• showed an approximately 1.5 fold increase in apoptotic cells in testis

decreased testis weight ( J:114675 )

• approximately 40% reduction in testis weight of 3-month old mice

homeostasis/metabolism

hyperglycemia ( J:114675 )

• observed under random feeding condition

decreased circulating testosterone level ( J:114675 )

• approximately 70% reduction

increased circulating insulin level ( J:114675 )

• plasma insulin levels were significantly higher under both random feeding and fasting conditions

impaired glucose tolerance ( J:114675 )

• susceptibility to glucose intolerance in male

insulin resistance ( J:114675 )

• reduced insulin sensitivity in both male and female mice

Allelic Composition	Akt1^tm1Hem/Akt1^tm1Hem Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Akt1^tm1Hem mutation (0 available); any Akt1 mutation (34 available)
Akt2^tm1Hem mutation (0 available); any Akt2 mutation (51 available)
Akt3^tm1Hem mutation (0 available); any Akt3 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:114675 )

• no triple homozygous mice were obtained from appropriate crosses implying embryonic lethality

Allelic Composition	Akt1^tm1Hem/Akt1⁺ Akt2^tm1Hem/Akt2^tm1Hem Akt3^tm1Hem/Akt3^tm1Hem
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:114675 )

• viable and fertile and showed no obvious defects except for a severe growth deficiency

decreased body weight ( J:114675 )

• body weight at the age of 12 weeks reduced around 40% of wild-type

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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