Analysis Tools
cardiovascular system
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• myocardium shows fibroblasts with abundant rough ER, suggesting some underlying fibrosis in trabeculae, although show no gross fibrosis
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• trabeculae tend to be larger than in wild-type
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• both intact and skinned trabeculae show impaired active force generation compared to wild-type, indicating reduced contractile function, however systolic blood pressure and heart rate are normal
• inotropic responses to increases of bath calcium concentrations, pacing frequency, and isoproterenol are reduced compared to wild-type
• skinned trabeculae have about 50% reduction of force development compared to wild-type
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• unstimulated trabeculae have greater passive force at increased sarcomere length compared to wild-type, indicating increased myocardial stiffness
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muscle
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• myocardium shows fibroblasts with abundant rough ER, suggesting some underlying fibrosis in trabeculae, although show no gross fibrosis
|
|
• trabeculae tend to be larger than in wild-type
|
|
• both intact and skinned trabeculae show impaired active force generation compared to wild-type, indicating reduced contractile function, however systolic blood pressure and heart rate are normal
• inotropic responses to increases of bath calcium concentrations, pacing frequency, and isoproterenol are reduced compared to wild-type
• skinned trabeculae have about 50% reduction of force development compared to wild-type
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