Phenotypes associated with this allele

• Allele Symbol: Tg(UCP3,UCP2)1Ful
• Allele Name: transgene insertion 1, Charles A Fuller
• Allele ID: MGI:3689922
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(UCP3,UCP2)1Ful/0	involves: C57BL/6J	MGI:3689930
tg2	Tg(UCP3,UCP2)1Ful/0	Not Specified	MGI:3689940

Genotype
MGI:3689930

tg1

• Allelic Composition: Tg(UCP3,UCP2)1Ful/0
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

improved righting response ( J:113539 )

• regaining of righting reflex is quicker on days 2, 3, and 4 of ethanol injections in UCP2-overexpressing mice compared to wild-type controls but on day 5, latencies are the same between genotypes

abnormal locomotor behavior ( J:113539 )

• mice recover and resume locomotion more quickly than wild-type on days 2, 3, and 4 of ethanol injections, compared to wild-type but on day 5, latencies are the same between genotypes

decreased thermal nociceptive threshold ( J:113539 )

• prior to ethanol injection, on first day of training, transgenic mice move away from hot plate at same pace as controls; 4 hours after ethanol treatment on day 1 and before and after ethanol injection on day 5 of treatment, mutants withdraw more rapidly from hot plate than control mice

Genotype
MGI:3689940

tg2

• Allelic Composition: Tg(UCP3,UCP2)1Ful/0
• Genetic Background: Not Specified

growth/size/body

increased lean body mass ( J:114746 )

• mice have a higher percent of fat-free mass than wild-type

adipose tissue

decreased white adipose tissue amount ( J:114746 )

• transgenic mice display reduced percent body fat (5.2%) vs wild-type (6.2%)

abnormal epididymal fat pad morphology ( J:114746 )

• mutants have less epididymal and mesenteric white adipose tissue than controls

• at 1 G, epididymal fat pad mass is smaller than in wild-type

behavior/neurological

behavior/neurological phenotype ( J:114746 )

N • no significant differences in the means, amplitudes or phases of activity between wild-type and mutants are observed at 1-G or 2-G exposure

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:114746 )

N • no significant differences in the means, amplitudes or phases of body temperature (T_b between wild-type and mutants are observed at 1-G or 2-G exposure