All Phenotypes Pgr<tm1.2Mlia> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pgr^tm1.2Mlia
targeted mutation 1.2, M Luisa Iruela-Arispe
MGI:3689427

Summary

2 genotypes

Allelic Composition	Pgr^tm1.2Mlia/Pgr^tm1.2Mlia
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgr^tm1.2Mlia mutation (0 available); any Pgr mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

failure of superovulation ( J:114465 )

• females examined for egg presence by flushing or histology are found to be anovulatory after exposure to superovulation hormonal regiments

female infertility ( J:114465 )

• homozygotes are sterile while heterozygous females and heterozygous males show normal fertility

Allelic Composition	Pgr^tm1.2Mlia/Pgr^tm1.2Mlia
Genetic Background	involves: 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgr^tm1.2Mlia mutation (0 available); any Pgr mutation (73 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal uterus development ( J:205553 )

• expression analysis indicates a defect in uterine differentiation

abnormal uterus physiology ( J:205553 )

• impairment in the increase in uterine weight and change in vascular permeability in response to P4

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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