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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pgrtm1.1Mlia
targeted mutation 1.1, M Luisa Iruela-Arispe
MGI:3689426
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pgrtm1.1Mlia/Pgrtm1.1Mlia involves: 129 * C57BL/6J MGI:3689573
cn2
 		Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0 		involves: 129X1/SvJ * FVB/N MGI:5566877


Genotype
MGI:3689573
hm1
Allelic
Composition		 Pgrtm1.1Mlia/Pgrtm1.1Mlia
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1Mlia mutation (0 available); any Pgr mutation (73 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:114465 )
• homozygous females are fully viable, fertile and phenotypically normal




Genotype
MGI:5566877
cn2
Allelic
Composition		 Pgrtm1.1Mlia/Pgrtm1.1Mlia
Tg(Cdh5-cre)7Mlia/0
Genetic
Background		 involves: 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pgrtm1.1Mlia mutation (0 available); any Pgr mutation (73 available)
Tg(Cdh5-cre)7Mlia mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
impaired embryo implantation ( J:205553 )
• 43% reduction in the number of implantation sites compared to controls
abnormal uterus physiology ( J:205553 )
• change in permeability of uterine vasculature following hormone treatment (E2 + P4) is significantly reduced
• increase in albumin extravasation during pregnancy is significantly reduced

cardiovascular system
abnormal vascular permeability ( J:205553 )
• changes in permeability of uterine vasculature following hormone treatment (E2 + P4) and during pregnancy are significantly reduced




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory