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Allele Symbol Allele Name Allele ID |
Tg(Ins2-Ccl19)2Cys transgene insertion 2, Jason G Cyster MGI:3689196 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• only small and medium-sized infiltrates develop, and become prominent only at >4 months of age
• fewer and smaller pancreatic infiltrates that are often observed in association with large blood vessels are observed compared to Ccl21b transgenics; B cells are found in greatest numbers in infiltrates, and CD4 T cells are more frequent than CD8 in pancreata of older mice
• infiltrates are less organized than in Ccl21b transgenic mice
• gp38+, BP3+, and ER-TR7+ stromal cell networks appear in infiltrates
• infiltrates display an invasive phenotype with individual T cells frequently seen in the islet cell mass; this is more apparent than in Ccl21b transgenic mice
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• results in development of high endothelial venules (HEVs) in the lymphoid tissue which are characterized by thick endothelium and addressin expression is seen
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/14/2024 MGI 6.23 |
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