Analysis Tools
mortality/aging
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• 34 of 135 die at a mean age of 224 days with a cumulative mortality of 25%
• premature death is sudden with no signs of heart failure
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cardiovascular system
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• observe degeneration of cardiomyocytes within larger fibrotic areas of the ventricles at 22 months of age
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• develop progressive cardiac fibrosis with age
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• exhibit an increase in left ventricular (LV) dP/dt max and the ratio of dP/dt max to dP/dt min
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• although at young ages exhibit enhanced left ventricle contractility, mutants show a loss in hypercontractility as they age
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• exhibit an increase in apoptotic cells in the ventricles at 12 months of age
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muscle
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• observe degeneration of cardiomyocytes within larger fibrotic areas of the ventricles at 22 months of age
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• exhibit an increase in left ventricular (LV) dP/dt max and the ratio of dP/dt max to dP/dt min
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• although at young ages exhibit enhanced left ventricle contractility, mutants show a loss in hypercontractility as they age
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• exhibit an increase in apoptotic cells in the ventricles at 12 months of age
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cellular
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• exhibit an increase in apoptotic cells in the ventricles at 12 months of age
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