Phenotypes associated with this allele

• Allele Symbol: H2-DMa^tm2Liz
• Allele Name: targeted mutation 2, Elizabeth K Bikoff
• Allele ID: MGI:3688434
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-DMa^tm2Liz/H2-DMa^tm2Liz	involves: C57BL/6 * C57BL/10 * C57BR * CBA	MGI:3689002

Genotype
MGI:3689002

hm1

• Allelic Composition: H2-DMa^tm2Liz/H2-DMa^tm2Liz
• Genetic Background: involves: C57BL/6 * C57BL/10 * C57BR * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased T cell proliferation ( J:111565 )

• CD4+ T cells show no proliferative response to wild-type spleen cells in culture

abnormal professional antigen presenting cell physiology ( J:111565 )

• splenocytes from mutants on the H-2^k background display enhanced peptide binding capacities, greater than wild-type or Cd74^tm1Liz mutant splenocytes

• splenocytes will bind OVA_323-339 which binds preferentially to MHC A^d-haplotype cells and does not bind in wild-type mice of this haplotype

abnormal antigen presentation via MHC class II ( J:111565 )

• mutants display isotype-specific antigen presentation defects; MHC A^k-restricted antigen presentation by cells is reduced compared to wild-type

• E^k-restricted T cells are efficiently stimulated by mutant splenocytes when incubated with hen egg lysozyme (HEL) antigen

hematopoietic system

decreased T cell proliferation ( J:111565 )

• CD4+ T cells show no proliferative response to wild-type spleen cells in culture

cellular

decreased T cell proliferation ( J:111565 )

• CD4+ T cells show no proliferative response to wild-type spleen cells in culture