All Phenotypes Tg(Tcrb2B4)1Mmd MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tcra-J^tm1Kgwa/Tcra-J^tm1Kgwa Tg(Tcrb2B4)1Mmd/0	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:3688406
cx2	Itk^tm1Ljb/Itk^tm1Ljb Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/?	involves: C3H/HeJ * C57BL/6 * C57BL/10	MGI:4354594
cx3	Tg(H2KmPCC)2939Stoe/0 Tg(Tcra2B4)1Mmd/0 Tg(Tcrb2B4)1Mmd/0	involves: C3H/HeJ * C57BL/6 * SJL	MGI:3688409
cx4	Dock2^tm1Tsas/Dock2^tm1Tsas Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/?	involves: C57BL/6	MGI:3690240

Allelic Composition	Tcra-J^tm1Kgwa/Tcra-J^tm1Kgwa Tg(Tcrb2B4)1Mmd/0
Genetic Background	involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:50143 )

• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly

increased double-positive T cell number ( J:50143 )

• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly

immune system

abnormal T cell differentiation ( J:50143 )

• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly

increased double-positive T cell number ( J:50143 )

• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly

Allelic Composition	Itk^tm1Ljb/Itk^tm1Ljb Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/?
Genetic Background	involves: C3H/HeJ * C57BL/6 * C57BL/10

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itk^tm1Ljb mutation (0 available); any Itk mutation (48 available)
Tg(Tcra2B4)1Mmd mutation (0 available)
Tg(Tcrb2B4)1Mmd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the percentages and absolute numbers of CD4⁺ single positive thymocytes is drastically reduced compared to wild-type and transgenic controls

• peripheral CD4 T cell numbers are also reduced

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:123795 )

• the percentages and absolute numbers of CD4⁺ single positive thymocytes is drastically reduced compared to wild-type and transgenic controls

• peripheral CD4 T cell numbers are also reduced

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased T cell proliferation ( J:50143 )

• mice have no in vitro response to cytochrome C while spleen cells from Tcra-knockin, transgenic Tcrb-expressing mice exhibit a vigorous proliferation response

decreased thymocyte number ( J:50143 )

• number of thymocytes (2-4 x 10⁶) in tolerant mice is reduced 30 to 40-fold compared with normal TCR transgenic mice (Tg(H2KmPCC)2939Stoe-negative, TcraTcrb-positive mice; 70-90 x 10⁶ cells)

abnormal T cell differentiation ( J:50143 )

• number of thymocytes is drastically reduced and few thymocytes undergo natural development using the endogenous Tcra/transgenic Tcrb chain compared to Tcra-knockin, transgenic Tcrb-expressing mice

hematopoietic system

decreased T cell proliferation ( J:50143 )

• mice have no in vitro response to cytochrome C while spleen cells from Tcra-knockin, transgenic Tcrb-expressing mice exhibit a vigorous proliferation response

decreased thymocyte number ( J:50143 )

• number of thymocytes (2-4 x 10⁶) in tolerant mice is reduced 30 to 40-fold compared with normal TCR transgenic mice (Tg(H2KmPCC)2939Stoe-negative, TcraTcrb-positive mice; 70-90 x 10⁶ cells)

abnormal T cell differentiation ( J:50143 )

endocrine/exocrine glands

decreased thymocyte number ( J:50143 )

• number of thymocytes (2-4 x 10⁶) in tolerant mice is reduced 30 to 40-fold compared with normal TCR transgenic mice (Tg(H2KmPCC)2939Stoe-negative, TcraTcrb-positive mice; 70-90 x 10⁶ cells)

cellular

decreased T cell proliferation ( J:50143 )

• mice have no in vitro response to cytochrome C while spleen cells from Tcra-knockin, transgenic Tcrb-expressing mice exhibit a vigorous proliferation response

Allelic Composition	Dock2^tm1Tsas/Dock2^tm1Tsas Tg(Tcra2B4)1Mmd/? Tg(Tcrb2B4)1Mmd/?
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock2^tm1Tsas mutation (1 available); any Dock2 mutation (142 available)
Tg(Tcra2B4)1Mmd mutation (0 available)
Tg(Tcrb2B4)1Mmd mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased double-positive T cell number ( J:84581 )

• numbers reduced to about 3% of what is seen in controls

• more susceptible to apoptosis

abnormal CD4-positive, alpha beta T cell morphology ( J:84581 )

• reduced in number and ratio in relation to CD8+ T cells is also reduced

abnormal T cell physiology ( J:84581 )

• proliferative responses are reduced

hematopoietic system

decreased double-positive T cell number ( J:84581 )

• numbers reduced to about 3% of what is seen in controls

• more susceptible to apoptosis

abnormal CD4-positive, alpha beta T cell morphology ( J:84581 )

• reduced in number and ratio in relation to CD8+ T cells is also reduced

abnormal T cell physiology ( J:84581 )

• proliferative responses are reduced

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