All Phenotypes Map2k6<tm1Ina> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Map2k6^tm1Ina
targeted mutation 1, Izumi Nakashima
MGI:3687978

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map2k6^tm1Ina/Map2k6^tm1Ina	involves: 129P2/OlaHsd	MGI:3692605
cx2	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcrLCMV)327Sdz/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3692612
cx3	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcraH-Y,TcrbH-Y)71Vbo/0	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J	MGI:3692608

Allelic Composition	Map2k6^tm1Ina/Map2k6^tm1Ina
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6^tm1Ina mutation (1 available); any Map2k6 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:100093 )

• in homozygotes, a reduced percentage of TCRalphabeta^int CD69^lo caspase-active thymocytes is observed compared to wild-type mice, while no difference in caspase-activities in TCRalphabeta^int is seen, compared to wild-type

• a lower percentage of TCRalphabeta^intCD69^lo cells show DNA fragmentation in the thymocyte cell population compared to wild-type

Allelic Composition	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcrLCMV)327Sdz/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6^tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
Tg(TcrLCMV)327Sdz mutation (8 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:100093 )

• upon antigenic stimulation by injection of LCMV, caspase activation and DNA fragmentation in the TCRalphabeta^int thymocyte population is reduced compared to Map2k6-sufficient transgenic mice, while levels in the TCRalphabeta^hi population are comparable

• upon antigenic stimulation by injection of LCMV, deletion of TCR CD4^hiCD8^hi cells is less efficient than in Map2k6-sufficient transgenic mice

Allelic Composition	Map2k6^tm1Ina/Map2k6^tm1Ina Tg(TcraH-Y,TcrbH-Y)71Vbo/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * DBA/2J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k6^tm1Ina mutation (1 available); any Map2k6 mutation (42 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

hematopoietic system

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

cellular

decreased apoptosis ( J:100093 )

• percentage of caspase-active cells in TCRalphabeta^intCD69^lo CD4^hiCD8^hi thymocyte population of males is lower than in Map2k6-sufficient transgene-expressing cells; as well, a smaller percentage of cells show DNA fragmentation

endocrine/exocrine glands

abnormal thymus cell ratio ( J:100093 )

• in males, an increased number of in TCRalphabeta^intCD69^lo CD4^loCD8^lo thymocytes is observed compared to Map2k6-sufficient transgenic mice

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