About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT14-Edn3)1Takk
transgene insertion 1, Takahiro Kusinada
MGI:3687548
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Mitfmi-vit/Mitfmi-vit
Tg(KRT14-Edn3)1Takk/? 		involves: C57BL/6 * C57BL/6J * DBA/2 MGI:3720190
tg2
 		Tg(KRT14-Edn3)1Takk/? B6.Cg-Tg(KRT14-Edn3)1Takk MGI:3720186
tg3
 		Tg(KRT14-Edn3)1Takk/? involves: C57BL/6 * DBA/2 MGI:3720188


Genotype
MGI:3720190
cx1
Allelic
Composition		 Mitfmi-vit/Mitfmi-vit
Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 involves: C57BL/6 * C57BL/6J * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitfmi-vit mutation (1 available); any Mitf mutation (72 available)
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal coat/hair pigmentation ( J:100658 )
• at 6 months fo age, mice lose pigmentation of dorsal hair
white spotting ( J:100658 )
• mice develop a ventral white spot similar to in Mitfmi-vit homozygotes
abnormal melanocyte morphology ( J:100658 )
• mice have an increased number of melanocytes but not as much as seen in Tg(KRT14-Edn3)1Takk mice
• melanocyte numbers decrease with age and mostly gone by 6 months

integument
abnormal coat/hair pigmentation ( J:100658 )
• at 6 months fo age, mice lose pigmentation of dorsal hair
white spotting ( J:100658 )
• mice develop a ventral white spot similar to in Mitfmi-vit homozygotes




Genotype
MGI:3720186
tg2
Allelic
Composition		 Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 B6.Cg-Tg(KRT14-Edn3)1Takk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal melanocyte morphology ( J:104881 )
• melanocyte numbers are increased

neoplasm
increased thyroid tumor incidence ( J:104881 )
• incidence of thyroid tumors is increased at 6 months of age

endocrine/exocrine glands
increased thyroid tumor incidence ( J:104881 )
• incidence of thyroid tumors is increased at 6 months of age




Genotype
MGI:3720188
tg3
Allelic
Composition		 Tg(KRT14-Edn3)1Takk/?
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-Edn3)1Takk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
darkened coat color ( J:100658 )
• mice have increased coat pigmentation and a ventral white spot at 2 months
abnormal skin pigmentation ( J:100658 )
• mice have increased pigment in their noses
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented
increased melanocyte number ( J:100658 )
• mice have an increased number of melanocytes

hearing/vestibular/ear
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

craniofacial
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

integument
darkened coat color ( J:100658 )
• mice have increased coat pigmentation and a ventral white spot at 2 months
abnormal skin pigmentation ( J:100658 )
• mice have increased pigment in their noses
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented

growth/size/body
increased ear pigmentation ( J:100658 )
• ears are heavily pigmented




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory