Analysis Tools
mortality/aging
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• >50% of transgenics (lines 73 and 275) die by 40 weeks of age; line 70 mice do not show significant premature death
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homeostasis/metabolism
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• massive mural thrombi adjacent to damaged tissue in atria are observed
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• upon necropsy, diseased mice show varying degrees of pleural effusions
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cardiovascular system
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• myocyte degeneration and vacuolization are observed in atria, consistent with myocarditis
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• associated with myocarditis with lymphocytic infiltrates
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• diseased mice upon death are found to have enlarged hearts with ischemic coloration
• most healthy-appearing mice display marked cardiac enlargement at 40 weeks
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• ventricular inflammatory lesions are composed of large numbers of CD4+ and CD8+ T cells with many F4/80 macrophages and few B cells
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• enlarged livers show changes characteristic of centrilobular hepatic necrosis and hemorrhage
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• many transgenic mice display symptoms of congestive heart failure; line 70 transgenics do not develop symptoms of congestive heart failure
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• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates
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myocarditis
(
J:88055
)
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• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis
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endocrine/exocrine glands
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• observed in transgenic and non-transgenic littermates with equal frequency
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• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes
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immune system
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• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates
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myocarditis
(
J:88055
)
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• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis
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• observed in transgenic and non-transgenic littermates with equal frequency
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• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes
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• transgenic mice line 73 show the highest prevalence and titers of cardiac tissue autoantibodies (16/18 mice are positive), while only 5/24 mice of line 70 are positive with lower antibody titers
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liver/biliary system
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• enlarged livers show changes characteristic of centrilobular hepatic necrosis and hemorrhage
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• livers show pathological changes characteristic of severe cardiac insufficiency and centrilobular hepatic necrosis and hemorrhage
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• upon necropsy, diseased mice show enlargement and darkening of the liver
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digestive/alimentary system
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• observed in transgenic and non-transgenic littermates with equal frequency
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behavior/neurological
muscle
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• myocyte degeneration and vacuolization are observed in atria, consistent with myocarditis
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• associated with myocarditis with lymphocytic infiltrates
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respiratory system
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• upon necropsy, diseased mice show varying degrees of pleural effusions
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• mice show acute onset of labored breathing
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growth/size/body
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• diseased mice upon death are found to have enlarged hearts with ischemic coloration
• most healthy-appearing mice display marked cardiac enlargement at 40 weeks
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• upon necropsy, diseased mice show enlargement and darkening of the liver
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