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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(HLA-DQA1,HLA-DQB1)70Myl
transgene insertion 70, Myra A Lipes
MGI:3687022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)70Myl/0 		NOD.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl MGI:3687027


Genotype
MGI:3687027
cx1
Allelic
Composition		 H2-Ab1b-tm1Gru/H2-Ab1b-tm1Gru
Tg(HLA-DQA1,HLA-DQB1)70Myl/0
Genetic
Background		 NOD.Cg-H2-Ab1b-tm1Gru Tg(HLA-DQA1,HLA-DQB1)70Myl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1b-tm1Gru mutation (11 available); any H2-Ab1 mutation (81 available)
Tg(HLA-DQA1,HLA-DQB1)70Myl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
myocardium necrosis ( J:88055 )
• associated with myocarditis with lymphocytic infiltrates
heart inflammation ( J:88055 )
• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates
myocarditis ( J:88055 )
• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis

digestive/alimentary system
salivary gland inflammation ( J:88055 )
• observed in transgenic and non-transgenic littermates with equal frequency

endocrine/exocrine glands
salivary gland inflammation ( J:88055 )
• observed in transgenic and non-transgenic littermates with equal frequency
insulitis ( J:88055 )
• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes

immune system
heart inflammation ( J:88055 )
• hearts show extensive mononuclear infiltrates in the atria; ventricles show focal infiltrates
myocarditis ( J:88055 )
• myocarditis development is transgene- and NOD-specific; the transgenics all exhibit myocarditis
salivary gland inflammation ( J:88055 )
• observed in transgenic and non-transgenic littermates with equal frequency
insulitis ( J:88055 )
• transgenic mice show insulitis, but pancreatic beta cell damage is not sufficient to result in clinical diabetes
increased autoantibody level ( J:88055 )
• transgenic mice line 73 show the highest prevalence and titers of cardiac tissue autoantibodies (16/18 mice are positive), while only 5/24 line 70 transgenics are positive and have lower antibody titers

muscle
myocardium necrosis ( J:88055 )
• associated with myocarditis with lymphocytic infiltrates

cellular
myocardium necrosis ( J:88055 )
• associated with myocarditis with lymphocytic infiltrates




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory