About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mapk1tm2Hed
targeted mutation 2, Stephen M Hedrick
MGI:3686889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mapk1tm2Hed/Mapk1tm2Hed involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3687230
ht2
 		Mapk1tm2Hed/Mapk1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3687231


Genotype
MGI:3687230
hm1
Allelic
Composition		 Mapk1tm2Hed/Mapk1tm2Hed
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Hed mutation (0 available); any Mapk1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:113280 )
• no homozygous mice are generated from 60 heterozygous matings




Genotype
MGI:3687231
ht2
Allelic
Composition		 Mapk1tm2Hed/Mapk1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk1tm2Hed mutation (0 available); any Mapk1 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
transmission ratio distortion ( J:113280 )
• transmission of deficient allele decreases with each generation in backcrosses to C57BL/6 such that by F4, there is only one male heterozygote out of 37 offspring
• background sensitivity when an F3 heterozygote is backcrossed to 129/Sv, the mutant allele shows 54% transmission




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory