Phenotypes associated with this allele

• Allele Symbol: Notch1^tm1Pst
• Allele Name: targeted mutation 1, Pamela Stanley
• Allele ID: MGI:3665446
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch1^tm1Pst/Notch1^tm1Pst	involves: 129/Sv * C57BL/6 * SJL	MGI:3687207

Genotype
MGI:3687207

hm1

• Allelic Composition: Notch1^tm1Pst/Notch1^tm1Pst
• Genetic Background: involves: 129/Sv * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:112097 )

• homozygotes die at ~E10.5 and display developmental defects to other reported Notch1-null embryos

embryo

embryonic growth retardation ( J:112097 )

• similar to reports of other nulls

abnormal embryonic tissue morphology ( J:112097 )

• similar to reports of other nulls

growth/size/body

embryonic growth retardation ( J:112097 )

• similar to reports of other nulls