All Phenotypes S100a10<tm1Jwo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

S100a10^tm1Jwo
targeted mutation 1, John N Wood
MGI:3665443

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	S100a10^tm1Jwo/S100a10^tm1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺	involves: 129 * C57BL/6	MGI:3687277

Allelic Composition	S100a10^tm1Jwo/S100a10^tm1Jwo Scn10a^tm2(cre)Jwo/Scn10a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
S100a10^tm1Jwo mutation (2 available); any S100a10 mutation (34 available)
Scn10a^tm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased single cell response intensity ( J:113256 )

• about a 50% decrease in tetrodotoxin-resistant current density in whole-cell voltage clamp assays of dorsal root ganglia neurons, but no difference in tetrodotoxin-sensitive current density

• decrease in total evoked neuron activity in wide dynamic range (WDR) spinal neurons following noxious pinch stimulation but not after noxious cold or brush stimulation

behavior/neurological

abnormal pain threshold ( J:113256 )

• increased pain threshold following noxious mechanical stimuli applied to the tail but not to the paw

• no significant difference in response to noxious radiant or in hotplate latency

allodynia ( J:113256 )

• reduction in mechanical allodynia following L5 spinal nerve injury

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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