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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sez6ltm1Hta
targeted mutation 1, Hiroshi Takeshima
MGI:3665420
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sez6ltm1Hta/Sez6ltm1Hta involves: 129 * C57BL MGI:3688098
cx2
 		Sez6tm1Hta/Sez6tm1Hta
Sez6ltm1Hta/Sez6ltm1Hta
Sez6l2tm1Hta/Sez6l2tm1Hta 		involves: 129 * C57BL MGI:3688101


Genotype
MGI:3688098
hm1
Allelic
Composition		 Sez6ltm1Hta/Sez6ltm1Hta
Genetic
Background		 involves: 129 * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sez6ltm1Hta mutation (0 available); any Sez6l mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:111556 )
• mice show slightly impaired coordination in the rotarod task




Genotype
MGI:3688101
cx2
Allelic
Composition		 Sez6tm1Hta/Sez6tm1Hta
Sez6ltm1Hta/Sez6ltm1Hta
Sez6l2tm1Hta/Sez6l2tm1Hta
Genetic
Background		 involves: 129 * C57BL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sez6l2tm1Hta mutation (0 available); any Sez6l2 mutation (33 available)
Sez6ltm1Hta mutation (0 available); any Sez6l mutation (42 available)
Sez6tm1Hta mutation (0 available); any Sez6 mutation (71 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired coordination ( J:111556 )
• in a thin rod test, null mice walk slowly and essentially are crawling along bar, compared to wild-type which traverse bar quickly and proficiently; mutant mice frequently stop and curl tail around bar
• in a rotarod test, null mice fail to stay on bar, showing significant impairment in all trials with little improvement

nervous system
abnormal Purkinje cell innervation ( J:111556 )
• Purkinje cell dendritic innervation by climbing fibers is abnormal; there is evidence of multiple innervation, with dendrites showing innervation by two climbing fibers
abnormal excitatory postsynaptic currents ( J:111556 )
• a higher percentage of Purkinje cells (PCs) in cerebellar slices display 2 or more discrete EPSCs than wild-type Purkinje cells
• PCs with multiple EPSCs have EPSCs with small amplitudes and slow rise times compared to wild-type
• EPSCs are elicited in all-or-none fashion and show paired-pulse depression in mutants




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory