About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tcra-Jtm1Kgwa
targeted mutation 1, Osami Kanagawa
MGI:3665411
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tcratm1Mom/Tcratm1Mom
Tcra-Jtm1Kgwa/Tcra-Jtm1Kgwa
involves: 129P2/OlaHsd * 129S2/SvPas * C3H/HeJ * C57BL/6J MGI:3688410
cx2
Tcra-Jtm1Kgwa/Tcra-Jtm1Kgwa
Tg(Tcrb2B4)1Mmd/0
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J MGI:3688406


Genotype
MGI:3688410
cx1
Allelic
Composition
Tcratm1Mom/Tcratm1Mom
Tcra-Jtm1Kgwa/Tcra-Jtm1Kgwa
Genetic
Background
involves: 129P2/OlaHsd * 129S2/SvPas * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra-Jtm1Kgwa mutation (0 available); any Tcra-J mutation (0 available)
Tcratm1Mom mutation (6 available); any Tcra mutation (98 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it

immune system
• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it




Genotype
MGI:3688406
cx2
Allelic
Composition
Tcra-Jtm1Kgwa/Tcra-Jtm1Kgwa
Tg(Tcrb2B4)1Mmd/0
Genetic
Background
involves: 129P2/OlaHsd * C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly

immune system
• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
04/23/2024
MGI 6.23
The Jackson Laboratory