Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra-Jtm1Kgwa mutation
(0 available);
any
Tcra-J mutation
(0 available)
Tcratm1Mom mutation
(6 available);
any
Tcra mutation
(98 available)
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hematopoietic system
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• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it
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immune system
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• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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hematopoietic system
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• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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immune system
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• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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