Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tcra-Jtm1Kgwa targeted mutation 1, Osami Kanagawa MGI:3665411 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it
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• majority of CD3+ double negative (DN) cells express the transgenic TCR alpha, but only 3-5% of double- and single-positive cells express it
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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• an increase in number from 5 to 50% in transgenic Tcra-expressing cells is observed in single positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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• an increase from 3 to 30% in transgenic Tcra-expressing cells is observed in double-positive cells; deletion of the transgenic TCR by secondary rearrangement is reduced significantly
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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