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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grm3tm1Ddsc
targeted mutation 1, Darryle D Schoepp
MGI:3665324
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Grm3tm1Ddsc/Grm3tm1Ddsc involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3690070


Genotype
MGI:3690070
hm1
Allelic
Composition		 Grm3tm1Ddsc/Grm3tm1Ddsc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grm3tm1Ddsc mutation (0 available); any Grm3 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal anxiety-related response ( J:113260 )
• injection of LY354740, an mGlu2/3r agonist, 30 minutes prior to testing, induced anxiolytic-like effects in 5 week old male wild-type as shown by increased time spent in the open and number of open-arm entries in the elevated-plus maze (EPM) test; in contrast, mutants showed no decrease in anxiety-related behavior with LY354740 treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory