About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Seletm1Dmil
targeted mutation 1, David Milstone
MGI:3665314
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Seletm1Dmil/Seletm1Dmil involves: 129S4/SvJae * C57BL/6J MGI:3690074


Genotype
MGI:3690074
hm1
Allelic
Composition		 Seletm1Dmil/Seletm1Dmil
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Seletm1Dmil mutation (3 available); any Sele mutation (51 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels

cellular
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels

hematopoietic system
abnormal leukocyte adhesion ( J:113169 )
• TNFa treatment to stimulate an inflammatory response resulted in a significantly lower amount of adhesion in mutants vs wild-type
• numbers of adherent cells in wild-type prior to treatment is 74 adherent cells/sq. mm and in mutants 83 cells/sq. mm.; after TNF treatment, in wild-type there are 1745 adherent cells/sq. mm while in mutants there are 798 cells/sq. mm
• in mutants, fewer dermal microvessels support high adhesion densities compared to wild-type mice; a similar trend is observed in mesenteric microvessels




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory