Phenotypes associated with this allele

• Allele Symbol: Pla2g15^tm1.1Jash
• Allele Name: targeted mutation 1.1, James A Shayman
• Allele ID: MGI:3665283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pla2g15^tm1.1Jash/Pla2g15^tm1.1Jash	involves: 129S1/Sv * C57BL/6	MGI:3690726

Genotype
MGI:3690726

hm1

• Allelic Composition: Pla2g15^tm1.1Jash/Pla2g15^tm1.1Jash
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal macrophage morphology ( J:111561 )

• increase in the size of alveolar macrophages and extensive lamellar inclusion bodies are present in alveolar macrophages and to a lesser extent in peritoneal macrophages

increased macrophage cell number ( J:111561 )

• for alveolar macrophages

increased macrophage derived foam cell number ( J:111561 )

• foam cells are seen in alveoli of lungs, heart, spleen and kidney

abnormal spleen morphology ( J:111561 )

• foam cells are seen throughout the spleen at 12 months of age

increased spleen weight ( J:111561 )

• greater than 4-fold increase in weight at 12 months of age

• spleen size is similar to wild-type at 4 months of age

abnormal macrophage physiology ( J:111561 )

• 2-fold increase in total phospholipid content of alveolar macrophages with marked accumulation of phosphethanolamine (PE) and phosphocholine (PC)

• 40% increase in total phospholipid content in peritoneal macrophages

reproductive system

reproductive system phenotype ( J:111561 )

N • fertile with normal litter sizes

respiratory system

abnormal pulmonary alveolus morphology ( J:111561 )

• alveolar foam cells are present; however, no significant increase in lung total phospholipid content is seen

cardiovascular system

abnormal heart morphology ( J:111561 )

• foam cells are seen throughout the heart at 12 months of age

liver/biliary system

hepatic steatosis ( J:111561 )

• foam cells are seen throughout the liver at 12 months of age

renal/urinary system

abnormal kidney morphology ( J:111561 )

• foam cells are seen throughout the kidneys at 12 months of age

hematopoietic system

abnormal macrophage morphology ( J:111561 )

• increase in the size of alveolar macrophages and extensive lamellar inclusion bodies are present in alveolar macrophages and to a lesser extent in peritoneal macrophages

increased macrophage cell number ( J:111561 )

• for alveolar macrophages

increased macrophage derived foam cell number ( J:111561 )

• foam cells are seen in alveoli of lungs, heart, spleen and kidney

abnormal spleen morphology ( J:111561 )

• foam cells are seen throughout the spleen at 12 months of age

increased spleen weight ( J:111561 )

• greater than 4-fold increase in weight at 12 months of age

• spleen size is similar to wild-type at 4 months of age

abnormal macrophage physiology ( J:111561 )

• 2-fold increase in total phospholipid content of alveolar macrophages with marked accumulation of phosphethanolamine (PE) and phosphocholine (PC)

• 40% increase in total phospholipid content in peritoneal macrophages

cellular

increased macrophage derived foam cell number ( J:111561 )

• foam cells are seen in alveoli of lungs, heart, spleen and kidney

growth/size/body

increased spleen weight ( J:111561 )

• greater than 4-fold increase in weight at 12 months of age

• spleen size is similar to wild-type at 4 months of age