Phenotypes associated with this allele

• Allele Symbol: Cryaa^2J
• Allele Name: 2 Jackson
• Allele ID: MGI:3665275
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cryaa^2J/Cryaa^2J	involves: BALB/c * FVB/N	MGI:3690118
cx2	Cryaa^2J/Cryaa^2J Tg(CAG-EGFP)1Osb/0	involves: BALB/c * C3H * C57BL/6 * FVB/N	MGI:3690119

Genotype
MGI:3690118

hm1

• Allelic Composition: Cryaa^2J/Cryaa^2J
• Genetic Background: involves: BALB/c * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:112248 )

• mice have small lenses with whole cataracts

small lens ( J:112248 )

• homozygotes have very small lenses; average lens wet weight is 60% less than wild-type at weaning

microphthalmia ( J:112248 )

• homozygotes exhibit microphthalmia

Genotype
MGI:3690119

cx2

• Allelic Composition: Cryaa^2J/Cryaa^2J; Tg(CAG-EGFP)1Osb/0
• Genetic Background: involves: BALB/c * C3H * C57BL/6 * FVB/N

vision/eye

abnormal lens morphology ( J:112248 )

• peripheral fiber cells of E16.5 lenses contain degenerated mitochondria with severe loss of matrix and cristae or with vacuoles

• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5

abnormal lens capsule morphology ( J:112248 )

• altered epithelial cells and degenerated fiber cells are seen in lenses; epithelial cells are detached from or aggregated beneath the lense capsule and posterior fiber cells are only partially elongated

abnormal lens epithelium morphology ( J:112248 )

• epithelium is severely altered; epithelial layer contains irregularly shaped cells and vesicle-like cellular structures, thus lacking polarized monolayer of cuboidal epithelial cells morphology seen in wild-type

• severely disrupted actin filaments are seen in contact regions between anterior epithelial cells and posterior fiber cells in lenses at E16.5